Estrogen receptor values in patients with benign breast disease

Joseph C. Allegra, Marc E. Lippman, Linda Green, Audrey Barlock, Richard Simon, E. B. Thompson, Karen K. Huff, Walter Griffin

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Tissue specimens from 55 female patients with benign breast disease were assayed for estrogen receptor. Twenty-one of 55 patients (38%) had tumors which contained significant amounts of estrogen receptor (<10 femtomoles/mg protein). Fibroadenomas possessed estrogen receptor more frequently than fibroystic disease or other benign breast tumors. Estrogen receptor positively did not correlate with laterality of the tumor; location or size of the largest nodule. Patients with estrogen receptor positive tumors had a mean age of 26.9 years compared to 36.4 years for patients with estrogen receptor negative tumors which were estrogen receptor positive compared to zero of 8 postmenopausal patients (p<0.05).

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
Issue number1
StatePublished - Jul 1979
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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