Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth

Robert B. Dickson; Mary E. Mcmanaway; Marc E. Lippman

doi:10.1126/science.3715461

Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth

Robert B. Dickson, Mary E. Mcmanaway, Marc E. Lippman

Medicine

Research output: Contribution to journal › Article › peer-review

222 Scopus citations

Abstract

The hormone 17β-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced 'second messengers' in estrogen-responsive growth of human breast cancer.

Original language	English (US)
Pages (from-to)	1540-1543
Number of pages	4
Journal	Science
Volume	232
Issue number	4757
DOIs	https://doi.org/10.1126/science.3715461
State	Published - Jan 1 1986

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abstract = "The hormone 17β-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced 'second messengers' in estrogen-responsive growth of human breast cancer.",

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AU - Mcmanaway, Mary E.

AU - Lippman, Marc E.

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N2 - The hormone 17β-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced 'second messengers' in estrogen-responsive growth of human breast cancer.

AB - The hormone 17β-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced 'second messengers' in estrogen-responsive growth of human breast cancer.

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Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth

Abstract

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