Abstract
The hormone 17β-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced 'second messengers' in estrogen-responsive growth of human breast cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1540-1543 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 232 |
| Issue number | 4757 |
| DOIs | |
| State | Published - Jan 1 1986 |
ASJC Scopus subject areas
- General
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Dickson, R. B., Mcmanaway, M. E., & Lippman, M. E. (1986). Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth. Science, 232(4757), 1540-1543. https://doi.org/10.1126/science.3715461