Estimation of Parameters in Binomial Crossover Designs

C. T. Le, Orlando W Gomez-Marin

Research output: Contribution to journalArticle

Abstract

Maximum Likelihood Estimation of order and treatment effects are derived for Binomial Crossover Designs. All estimators and estimated covariance and variances have closed forms and can be easily evaluated. These results are useful for use in multi‐center clinical trials.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalBiometrical Journal
Volume26
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

Keywords

  • Binomial Crossover Design
  • Estimation of Parameters
  • Multi‐center Clinical Trials

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Statistics and Probability
  • Medicine(all)

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