Establishment and Characterization of Three New Continuous Cell Lines Derived from Human Breast Carcinomas

Linda W. Engel, Nathaniel A. Young, Tommie Sue Tralka, Marc E. Lippman, Stephen J. O'Brien, M. Mary, Jo Joyce

Research output: Contribution to journalArticle

351 Scopus citations

Abstract

Three continuous lines of mammary tumor cells (ZR-75-1, ZR-75-27, and ZR-75-30) have been established from malignant effusions of two women with breast cancer. Differentiated properties expressed by each cell line include: (a) epithelial morphology (by light and electron microscopy) resembling that of the parental tumors; (b) presence of receptors for estrogen and other steroid hormones; and (c) growth responsiveness to estrogen and/or progesterone. All three cell lines possess human karyotypes that differ from one another in modal chromosome number as well as in characteristic marker chromosomes. Two of the cultures (ZR-75-27 and ZR-75-30), although derived from the same patient, have stable differences in their karyotypes.

Original languageEnglish (US)
Pages (from-to)3352-3364
Number of pages13
JournalCancer Research
Volume38
Issue number10
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Engel, L. W., Young, N. A., Tralka, T. S., Lippman, M. E., O'Brien, S. J., Mary, M., & Joyce, J. (1978). Establishment and Characterization of Three New Continuous Cell Lines Derived from Human Breast Carcinomas. Cancer Research, 38(10), 3352-3364.