Establishment and characterization of three new continuous cell lines derived from human breast carcinomas

L. W. Engel, N. A. Young, T. S. Tralka, Marc E Lippman, S. J. O'Brien, M. J. Joyce

Research output: Contribution to journalArticle

350 Citations (Scopus)

Abstract

Three continuous lines of mammary tumor cells (ZR-75-1, ZR-75-27, and ZR-75-30) have been established from malignant effusions of two women with breast cancer. Differentiated properties expressed by each cell line include: (a) epithelial morphology (by light and electron microscopy) resembling that of the parental tumors; (b) presence of receptors for estrogen and other steroid hormones; and (c) growth responsiveness to estrogen and/or progesterone. All three cell lines possess human karyotypes that differ from one another in modal chromosome number as well as in characteristic marker chromosomes. Two of the cultures (ZR-75-27 and ZR-75-30), although derived from the same patient, have stable differences in their karyotypes.

Original languageEnglish
Pages (from-to)3352-3364
Number of pages13
JournalCancer Research
Volume38
Issue number10
StatePublished - Dec 1 1978
Externally publishedYes

Fingerprint

Karyotype
Breast Neoplasms
Cell Line
Genetic Markers
Estrogen Receptors
Progesterone
Electron Microscopy
Estrogens
Chromosomes
Steroids
Hormones
Light
Growth
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Engel, L. W., Young, N. A., Tralka, T. S., Lippman, M. E., O'Brien, S. J., & Joyce, M. J. (1978). Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Research, 38(10), 3352-3364.

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. / Engel, L. W.; Young, N. A.; Tralka, T. S.; Lippman, Marc E; O'Brien, S. J.; Joyce, M. J.

In: Cancer Research, Vol. 38, No. 10, 01.12.1978, p. 3352-3364.

Research output: Contribution to journalArticle

Engel, LW, Young, NA, Tralka, TS, Lippman, ME, O'Brien, SJ & Joyce, MJ 1978, 'Establishment and characterization of three new continuous cell lines derived from human breast carcinomas', Cancer Research, vol. 38, no. 10, pp. 3352-3364.
Engel LW, Young NA, Tralka TS, Lippman ME, O'Brien SJ, Joyce MJ. Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Research. 1978 Dec 1;38(10):3352-3364.
Engel, L. W. ; Young, N. A. ; Tralka, T. S. ; Lippman, Marc E ; O'Brien, S. J. ; Joyce, M. J. / Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. In: Cancer Research. 1978 ; Vol. 38, No. 10. pp. 3352-3364.
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