Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

Allison L Bayer, Aixin Yu, Dennis Adeegbe, Thomas Malek

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Although many aspects of CD4+CD25+ T regulatory (Treg) cell development remain largely unknown, signaling through the IL-2R represents one feature for the production of Treg cells. Therefore, the present study was undertaken to further define early developmental steps in the production of Treg cells, including a more precise view on the role of interleukin (IL)-2 in this process. After adoptive transfer of wild-type Treg cells into neonatal IL-2Rβ -/- mice, only a small fraction of donor Treg cells selectively seeded the lymph node (LN). These donor Treg cells underwent rapid and extensive IL-2-dependent proliferation, followed by subsequent trafficking to the spleen. Thus, IL-2 is essential for T reg cell proliferation in neonatal LN. The number and distribution of Treg cells in the periphery of normal neonatal mice closely paralleled that seen for IL-2Rβ-/- mice that received T reg cells. However, for normal neonates, blockade of IL-2 decreased Treg cells in both the thymus and LN. Therefore, two steps of T reg cell development depend upon IL-2 in neonatal mice, thymus production, and subsequent expansion in the LN.

Original languageEnglish
Pages (from-to)769-777
Number of pages9
JournalJournal of Experimental Medicine
Volume201
Issue number5
DOIs
StatePublished - Mar 7 2005

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Regulatory T-Lymphocytes
Interleukin-2
Interleukins
Lymph Nodes
Thymus Gland
Adoptive Transfer
Spleen
Cell Proliferation

ASJC Scopus subject areas

  • Immunology

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Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period. / Bayer, Allison L; Yu, Aixin; Adeegbe, Dennis; Malek, Thomas.

In: Journal of Experimental Medicine, Vol. 201, No. 5, 07.03.2005, p. 769-777.

Research output: Contribution to journalArticle

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