Erythropoietin (Ep) Production and Kupffer Cell Alterations following Nephrectomy, Hypoxia, or Combined Nephrectomy and Hypoxia

Brian A. Naughton; David J. Birnbach; Philip Liu; Gail A. Kolks; Ming Z. Tung; Sam J. Piliero; Albert S. Gordon

doi:10.3181/00379727-160-40413

Erythropoietin (Ep) Production and Kupffer Cell Alterations following Nephrectomy, Hypoxia, or Combined Nephrectomy and Hypoxia

Brian A. Naughton, David J. Birnbach, Philip Liu, Gail A. Kolks, Ming Z. Tung, Sam J. Piliero, Albert S. Gordon

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hepatic cells were evaluated using scintillation scanning and counting, autoradiography, and planimetry under conditions favoring extrarenal Ep production. In general, Kupffer cell activity paralleled Ep production whereas the liver parenchymal cells did not manifest significant changes. The studies suggest that the Kupffer cell may be an extrarenal cellular site of Ep production.

Original language	English (US)
Pages (from-to)	170-174
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	160
Issue number	2
DOIs	https://doi.org/10.3181/00379727-160-40413
State	Published - Feb 1979
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.3181/00379727-160-40413

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Erythropoietin (Ep) Production and Kupffer Cell Alterations following Nephrectomy, Hypoxia, or Combined Nephrectomy and Hypoxia. / Naughton, Brian A.; Birnbach, David J.; Liu, Philip; Kolks, Gail A.; Tung, Ming Z.; Piliero, Sam J.; Gordon, Albert S.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 160, No. 2, 02.1979, p. 170-174.

Research output: Contribution to journal › Article › peer-review

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title = "Erythropoietin (Ep) Production and Kupffer Cell Alterations following Nephrectomy, Hypoxia, or Combined Nephrectomy and Hypoxia",

abstract = "Hepatic cells were evaluated using scintillation scanning and counting, autoradiography, and planimetry under conditions favoring extrarenal Ep production. In general, Kupffer cell activity paralleled Ep production whereas the liver parenchymal cells did not manifest significant changes. The studies suggest that the Kupffer cell may be an extrarenal cellular site of Ep production.",

author = "Naughton, {Brian A.} and Birnbach, {David J.} and Philip Liu and Kolks, {Gail A.} and Tung, {Ming Z.} and Piliero, {Sam J.} and Gordon, {Albert S.}",

note = "Funding Information: This work was supported by grants from the National Heart, Lung and Blood Institute of the N.I.H., U.S.P.H.S. (5R01 HLB03357-20) and from the New York State Health Research Council (HRC No. 877). 2 1979 160 2 170 174 ",

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AU - Naughton, Brian A.

AU - Birnbach, David J.

AU - Liu, Philip

AU - Kolks, Gail A.

AU - Tung, Ming Z.

AU - Piliero, Sam J.

AU - Gordon, Albert S.

N1 - Funding Information: This work was supported by grants from the National Heart, Lung and Blood Institute of the N.I.H., U.S.P.H.S. (5R01 HLB03357-20) and from the New York State Health Research Council (HRC No. 877). 2 1979 160 2 170 174

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N2 - Hepatic cells were evaluated using scintillation scanning and counting, autoradiography, and planimetry under conditions favoring extrarenal Ep production. In general, Kupffer cell activity paralleled Ep production whereas the liver parenchymal cells did not manifest significant changes. The studies suggest that the Kupffer cell may be an extrarenal cellular site of Ep production.

AB - Hepatic cells were evaluated using scintillation scanning and counting, autoradiography, and planimetry under conditions favoring extrarenal Ep production. In general, Kupffer cell activity paralleled Ep production whereas the liver parenchymal cells did not manifest significant changes. The studies suggest that the Kupffer cell may be an extrarenal cellular site of Ep production.

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Erythropoietin (Ep) Production and Kupffer Cell Alterations following Nephrectomy, Hypoxia, or Combined Nephrectomy and Hypoxia

Abstract

ASJC Scopus subject areas

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