Erythrocytic Abnormalities in Experimental Malaria

James N. George; Donna J. Wicker; Bernard J. Fogel; Charles E. Shields; Marcel E. Conrad

doi:10.3181/00379727-124-31931

Erythrocytic Abnormalities in Experimental Malaria

James N. George, Donna J. Wicker, Bernard J. Fogel, Charles E. Shields, Marcel E. Conrad

Office of the Dean, Medical

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Studies of erythroeytic indices and osmotic response revealed the presence of 2 abnormal populations of cells in hamsters infected with Plasmodium bergkei. One population consisted of mature nonpar asitized cells which became abnormally small and spherocytic with a diminished cellular surface area. This cell shrinkage could result from the hypersplenism of malaria or possibly from immunologic membrane damage. The other population was composed of parasitized re-ticulocytes which exhibited an increased rate of swelling in hypotonic saline, indicating impairment of the normal restricted cation permeability.

Original language	English (US)
Pages (from-to)	1086-1090
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	124
Issue number	4
DOIs	https://doi.org/10.3181/00379727-124-31931
State	Published - Apr 1967

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.3181/00379727-124-31931

Fingerprint Dive into the research topics of 'Erythrocytic Abnormalities in Experimental Malaria'. Together they form a unique fingerprint.

Cite this

@article{38750bf2cf024afc9a93f9368b4566fd,

title = "Erythrocytic Abnormalities in Experimental Malaria",

abstract = "Studies of erythroeytic indices and osmotic response revealed the presence of 2 abnormal populations of cells in hamsters infected with Plasmodium bergkei. One population consisted of mature nonpar asitized cells which became abnormally small and spherocytic with a diminished cellular surface area. This cell shrinkage could result from the hypersplenism of malaria or possibly from immunologic membrane damage. The other population was composed of parasitized re-ticulocytes which exhibited an increased rate of swelling in hypotonic saline, indicating impairment of the normal restricted cation permeability.",

author = "George, {James N.} and Wicker, {Donna J.} and Fogel, {Bernard J.} and Shields, {Charles E.} and Conrad, {Marcel E.}",

year = "1967",

month = apr,

doi = "10.3181/00379727-124-31931",

language = "English (US)",

volume = "124",

pages = "1086--1090",

journal = "Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "Society for Experimental Biology and Medicine",

number = "4",

}

TY - JOUR

T1 - Erythrocytic Abnormalities in Experimental Malaria

AU - George, James N.

AU - Wicker, Donna J.

AU - Fogel, Bernard J.

AU - Shields, Charles E.

AU - Conrad, Marcel E.

PY - 1967/4

Y1 - 1967/4

N2 - Studies of erythroeytic indices and osmotic response revealed the presence of 2 abnormal populations of cells in hamsters infected with Plasmodium bergkei. One population consisted of mature nonpar asitized cells which became abnormally small and spherocytic with a diminished cellular surface area. This cell shrinkage could result from the hypersplenism of malaria or possibly from immunologic membrane damage. The other population was composed of parasitized re-ticulocytes which exhibited an increased rate of swelling in hypotonic saline, indicating impairment of the normal restricted cation permeability.

AB - Studies of erythroeytic indices and osmotic response revealed the presence of 2 abnormal populations of cells in hamsters infected with Plasmodium bergkei. One population consisted of mature nonpar asitized cells which became abnormally small and spherocytic with a diminished cellular surface area. This cell shrinkage could result from the hypersplenism of malaria or possibly from immunologic membrane damage. The other population was composed of parasitized re-ticulocytes which exhibited an increased rate of swelling in hypotonic saline, indicating impairment of the normal restricted cation permeability.

UR - http://www.scopus.com/inward/record.url?scp=0014072289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014072289&partnerID=8YFLogxK

U2 - 10.3181/00379727-124-31931

DO - 10.3181/00379727-124-31931

M3 - Article

C2 - 6024814

AN - SCOPUS:0014072289

VL - 124

SP - 1086

EP - 1090

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 0037-9727

IS - 4

ER -

Erythrocytic Abnormalities in Experimental Malaria

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this