Erythrocytic Abnormalities in Experimental Malaria

James N. George, Donna J. Wicker, Bernard J. Fogel, Charles E. Shields, Marcel E. Conrad

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Studies of erythroeytic indices and osmotic response revealed the presence of 2 abnormal populations of cells in hamsters infected with Plasmodium bergkei. One population consisted of mature nonpar asitized cells which became abnormally small and spherocytic with a diminished cellular surface area. This cell shrinkage could result from the hypersplenism of malaria or possibly from immunologic membrane damage. The other population was composed of parasitized re-ticulocytes which exhibited an increased rate of swelling in hypotonic saline, indicating impairment of the normal restricted cation permeability.

Original languageEnglish (US)
Pages (from-to)1086-1090
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume124
Issue number4
DOIs
StatePublished - Apr 1967

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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