Erythrocyte choline concentrations are elevated in manic patients

R. S. Jope, D. J. Jenden, B. E. Ehrlich, J. M. Diamond, L. F. Gosenfeld

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The intracellular choline concentration in erythrocytes of manic patients who never had lithium therapy was 3 times the value for normal human subjects. Lithium therapy increased this value to 11 times normal, and the increase began within the first 2 days of lithium therapy. Plasma choline concentration was normal in untreated manic patients and did not change during lithium therapy.

Original languageEnglish (US)
Pages (from-to)6144-6146
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number10 II
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • General


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