Erythrocyte choline concentrations are elevated in manic patients

R. S. Jope, D. J. Jenden, B. E. Ehrlich, J. M. Diamond, L. F. Gosenfeld

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Abstract

The intracellular choline concentration in erythrocytes of manic patients who never had lithium therapy was 3 times the value for normal human subjects. Lithium therapy increased this value to 11 times normal, and the increase began within the first 2 days of lithium therapy. Plasma choline concentration was normal in untreated manic patients and did not change during lithium therapy.

Original languageEnglish (US)
Pages (from-to)6144-6146
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number10 II
DOIs
StatePublished - Dec 1 1980
Externally publishedYes

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