EQTL epistasis - challenges and computational approaches

Yang Huang, Stefan Wuchty, Teresa M. Przytycka

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

The determination of expression quantitative trait loci (eQTL) epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step toward the thorough understanding of gene regulation. Since gene expression has emerged as an "intermediate" molecular phenotype eQTL epistasis might help to explain the relationship between genotype and higher level organismal phenotypes such as diseases. A characteristic feature of eQTL analysis is the big number of tests required to identify associations between gene expression and genetic loci variability. This problem is aggravated, when epistatic effects between eQTLs are analyzed. In this review, we discuss recent algorithmic approaches for the detection of eQTL epistasis and highlight lessons that can be learned from current methods.

Original languageEnglish (US)
Article numberArticle 51
JournalFrontiers in Genetics
Volume4
Issue numberMAY
DOIs
StatePublished - Sep 11 2013
Externally publishedYes

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Keywords

  • EQTL
  • Epistasis
  • Genetic association
  • Genetic crosses
  • Network modules

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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