Epstein–Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: a review

Mario L. Marques-Piubelli, Yessenia I. Salas, Carlos Pachas, Renato Becker-Hecker, Francisco Vega, Roberto N. Miranda

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas associated with Epstein–Barr virus (EBV). In some of these diseases—such as EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified—virus detection is required for the diagnosis, while in others its detection is not necessary for diagnosis. EBV infection has three main latency patterns (types III, II, and I). Different latency patterns are found in different LPD types and are related to the host immune system status. For each of the LPDs/lymphomas, we discuss the clinical presentation, epidemiology, pathology, immunophenotype, and genetic or molecular basis. We provide data for a better understanding of the relationships among the discussed diseases and other information that can be useful in differential diagnosis. Not included in this review are classic Hodgkin lymphoma and some specific variants of DLBCL, as these entities are discussed in separate reviews in this issue.

Original languageEnglish (US)
Pages (from-to)40-52
Number of pages13
Issue number1
StatePublished - Jan 2020
Externally publishedYes


  • B-cell lymphoma
  • Epstein–Barr virus
  • HHV-8
  • HIV
  • diffuse large B-cell lymphoma
  • fibrin-associated large cell lymphoma
  • iatrogenic immunodeficiency
  • immunodeficiency
  • large cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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