Epstein-Barr Virus–Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting: An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?

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7 Scopus citations

Abstract

Objectives: Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. The common and indolent B-cell lymphomas, including extranodal marginal zone lymphomas (ENMZLs) of mucosa-associated lymphoid tissue (MALT), are excluded from the category of PTLD in the current World Health Organization classification. Methods: We report a case of Epstein-Barr virus (EBV)–positive bronchial-associated lymphoid tissue (BALT) lymphoma involving the lungs of a transplant patient. Results: Aside from history of cardiac transplant, young patient age, and EBV positivity, the histopathologic findings were indistinguishable from usual BALT lymphoma. Conclusions: We review the literature of ENMZL occurring in immunocompromised patients and present this case for consideration that this specific entity is a PTLD. We believe that additional studies might lend strength to the hypothesis that this particular group of EBV-positive, posttransplant ENMZLs merits classification and management as PTLDs.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalAmerican journal of clinical pathology
Volume149
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Bronchial-associated lymphoid tissue
  • Epstein-Barr virus
  • Extranodal marginal zone lymphoma
  • Posttransplant lymphoproliferative disorder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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