Epithelioid hemangioma of bone revisited: A study of 50 cases

G. Petur Nielsen, Amitabh Srivastava, Susan Kattapuram, Vikram Deshpande, John X. O'Connell, Chas D. Mangham, Andrew E. Rosenberg

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The clinical and pathologic features of 50 epithelioid hemangiomas of bone are analyzed. There were 29 males and 21 females who ranged in age from 10 to 75 (mean 35) years. The tumors arose in long tubular bones (40%), short tubular bones of the distal lower extremity (18%), flat bones (18%), vertebrae (16%), and small bones of the hands (8%). Nine patients (18%) had involvement of more than 1 bone. Radiographically, the lesions were lucent and well marginated. Microscopically, the neoplasms had a lobular architecture and were composed of epithelioid endothelial cells that formed obvious vascular lumina or grew in solid sheets. No hyalinized or solid appearing extracellular myxoid matrix was present. Thirty-five patients were treated with curettage, 13 patients had a local resection and 2 patients only had a biopsy. One patient had local lymph node involvement. Three patients were treated with surgery and radiation therapy. Follow-up information revealed that 4 patients experienced a local recurrence; and 1 patient developed limited involvement of a regional lymph node. Epithelioid hemangioma of bone is a benign lesion that may be multifocal and affect separate tissue and is successfully treated with curettage or marginal en bloc excision.

Original languageEnglish (US)
Pages (from-to)270-277
Number of pages8
JournalAmerican Journal of Surgical Pathology
Issue number2
StatePublished - Feb 2009
Externally publishedYes


  • Bone
  • Epithelioid hemangioma
  • Hemangioma
  • Vascular tumor

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)


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