Epithelial tumours induced by a Herpesvirus oncogene in transgenic mice

Carol Murphy, Claudia Kretschmer, Brigitte Biesinger, Johannes Beckers, Jae Jung, Ronald C. Desrosiers, Hans Konrad Müller-Hermelink, Bernhard W. Fleckenstein, Ulrich Rüther

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

To investigate the role of herpesviral genes in tumourigenesis, transgenic mice were generated expressing STP-C, a transformation associated protein of the lymphoma inducing herpes virus saimiri. Epithelial tumours developed in the salivary gland, pancreas, thymus and liver of transgenic mice within the first weeks of life. Thus, the target cells for tumour formation in the transgenic mice were surprisingly different from those of the herpesvirus from which the oncogene was derived. Our results identify STP-C as a herpesvirus oncogene sufficient for tumour induction without the cooperation of other viral gene products. Furthermore, the results demonstrate pleiotropic transforming capabilities of the STP-C oncogene and suggest that the specificity of lymphoma induction by the virus is determined by factors other than the oncogene itself.

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalOncogene
Volume9
Issue number1
StatePublished - Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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