Epithelial ingrowth after descemet stripping automated endothelial keratoplasty

Description of cases and assessment with anterior segment optical coherence tomography

Leejee H. Suh, Mohamed Abou Shousha, Roberta U. Ventura, Jeremy Z. Kieval, Victor L Perez Quinones, Jianhua Wang, Sander Dubovy, Steven I. Rosenfeld, William W Culbertson, Eduardo C Alfonso, Richard Forster

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

PURPOSE:: To describe 5 cases of epithelial ingrowth after Descemet stripping automated endothelial keratoplasty (DSAEK) and the use of anterior segment optical coherence tomography (AS-OCT) to describe the areas of ingrowth. METHODS:: Five cases with epithelial ingrowth after DSAEK were examined with commercially available AS-OCT and/or a novel custom-built ultrahigh resolution (UHR) AS-OCT. Argon laser photocoagulation was also used to confirm epithelial ingrowth on the iris surface. Pathological evidence of epithelial ingrowth was noted in an eye that underwent corneoscleral grafting for extensive ingrowth through a fistulous tract. RESULTS:: Epithelial ingrowth was solely in the graft-host interface in 1 case and in both the interface and retrocorneal and iris surfaces in 4 cases. Argon laser photocoagulation on the iris confirmed epithelial ingrowth in 4 cases. The areas of epithelial ingrowth were imaged in 1 case with the Visante AS-OCT and in 3 cases with an UHR-OCT. In 1 case, block excision with corneoscleral grafting was required. CONCLUSIONS:: Epithelial ingrowth can occur after DSAEK. This series reports 5 cases of epithelial ingrowth into the interface and/or the retrocorneal surface after DSAEK. Imaging with AS-OCT, specifically the UHR-OCT, and argon laser photocoagulation can help confirm the diagnosis. UHR-OCT imaging of the interface and retrocorneal surfaces can provide clues to the origin of epithelial ingrowth. Four cases were observed. One case underwent corneoscleral grafting with histological confirmation of epithelial ingrowth.

Original languageEnglish
Pages (from-to)528-534
Number of pages7
JournalCornea
Volume30
Issue number5
DOIs
StatePublished - May 1 2011

Fingerprint

Descemet Stripping Endothelial Keratoplasty
Optical Coherence Tomography
Light Coagulation
Argon
Iris
Lasers
Transplants

Keywords

  • anterior segment optical coherence tomography
  • Descemet stripping automated endothelial keratoplasty
  • epithelial ingrowth

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Epithelial ingrowth after descemet stripping automated endothelial keratoplasty : Description of cases and assessment with anterior segment optical coherence tomography. / Suh, Leejee H.; Abou Shousha, Mohamed; Ventura, Roberta U.; Kieval, Jeremy Z.; Perez Quinones, Victor L; Wang, Jianhua; Dubovy, Sander; Rosenfeld, Steven I.; Culbertson, William W; Alfonso, Eduardo C; Forster, Richard.

In: Cornea, Vol. 30, No. 5, 01.05.2011, p. 528-534.

Research output: Contribution to journalArticle

@article{e3e74a8a7a494e0bbf902f069868971f,
title = "Epithelial ingrowth after descemet stripping automated endothelial keratoplasty: Description of cases and assessment with anterior segment optical coherence tomography",
abstract = "PURPOSE:: To describe 5 cases of epithelial ingrowth after Descemet stripping automated endothelial keratoplasty (DSAEK) and the use of anterior segment optical coherence tomography (AS-OCT) to describe the areas of ingrowth. METHODS:: Five cases with epithelial ingrowth after DSAEK were examined with commercially available AS-OCT and/or a novel custom-built ultrahigh resolution (UHR) AS-OCT. Argon laser photocoagulation was also used to confirm epithelial ingrowth on the iris surface. Pathological evidence of epithelial ingrowth was noted in an eye that underwent corneoscleral grafting for extensive ingrowth through a fistulous tract. RESULTS:: Epithelial ingrowth was solely in the graft-host interface in 1 case and in both the interface and retrocorneal and iris surfaces in 4 cases. Argon laser photocoagulation on the iris confirmed epithelial ingrowth in 4 cases. The areas of epithelial ingrowth were imaged in 1 case with the Visante AS-OCT and in 3 cases with an UHR-OCT. In 1 case, block excision with corneoscleral grafting was required. CONCLUSIONS:: Epithelial ingrowth can occur after DSAEK. This series reports 5 cases of epithelial ingrowth into the interface and/or the retrocorneal surface after DSAEK. Imaging with AS-OCT, specifically the UHR-OCT, and argon laser photocoagulation can help confirm the diagnosis. UHR-OCT imaging of the interface and retrocorneal surfaces can provide clues to the origin of epithelial ingrowth. Four cases were observed. One case underwent corneoscleral grafting with histological confirmation of epithelial ingrowth.",
keywords = "anterior segment optical coherence tomography, Descemet stripping automated endothelial keratoplasty, epithelial ingrowth",
author = "Suh, {Leejee H.} and {Abou Shousha}, Mohamed and Ventura, {Roberta U.} and Kieval, {Jeremy Z.} and {Perez Quinones}, {Victor L} and Jianhua Wang and Sander Dubovy and Rosenfeld, {Steven I.} and Culbertson, {William W} and Alfonso, {Eduardo C} and Richard Forster",
year = "2011",
month = "5",
day = "1",
doi = "10.1097/ICO.0b013e3181fb8149",
language = "English",
volume = "30",
pages = "528--534",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Epithelial ingrowth after descemet stripping automated endothelial keratoplasty

T2 - Description of cases and assessment with anterior segment optical coherence tomography

AU - Suh, Leejee H.

AU - Abou Shousha, Mohamed

AU - Ventura, Roberta U.

AU - Kieval, Jeremy Z.

AU - Perez Quinones, Victor L

AU - Wang, Jianhua

AU - Dubovy, Sander

AU - Rosenfeld, Steven I.

AU - Culbertson, William W

AU - Alfonso, Eduardo C

AU - Forster, Richard

PY - 2011/5/1

Y1 - 2011/5/1

N2 - PURPOSE:: To describe 5 cases of epithelial ingrowth after Descemet stripping automated endothelial keratoplasty (DSAEK) and the use of anterior segment optical coherence tomography (AS-OCT) to describe the areas of ingrowth. METHODS:: Five cases with epithelial ingrowth after DSAEK were examined with commercially available AS-OCT and/or a novel custom-built ultrahigh resolution (UHR) AS-OCT. Argon laser photocoagulation was also used to confirm epithelial ingrowth on the iris surface. Pathological evidence of epithelial ingrowth was noted in an eye that underwent corneoscleral grafting for extensive ingrowth through a fistulous tract. RESULTS:: Epithelial ingrowth was solely in the graft-host interface in 1 case and in both the interface and retrocorneal and iris surfaces in 4 cases. Argon laser photocoagulation on the iris confirmed epithelial ingrowth in 4 cases. The areas of epithelial ingrowth were imaged in 1 case with the Visante AS-OCT and in 3 cases with an UHR-OCT. In 1 case, block excision with corneoscleral grafting was required. CONCLUSIONS:: Epithelial ingrowth can occur after DSAEK. This series reports 5 cases of epithelial ingrowth into the interface and/or the retrocorneal surface after DSAEK. Imaging with AS-OCT, specifically the UHR-OCT, and argon laser photocoagulation can help confirm the diagnosis. UHR-OCT imaging of the interface and retrocorneal surfaces can provide clues to the origin of epithelial ingrowth. Four cases were observed. One case underwent corneoscleral grafting with histological confirmation of epithelial ingrowth.

AB - PURPOSE:: To describe 5 cases of epithelial ingrowth after Descemet stripping automated endothelial keratoplasty (DSAEK) and the use of anterior segment optical coherence tomography (AS-OCT) to describe the areas of ingrowth. METHODS:: Five cases with epithelial ingrowth after DSAEK were examined with commercially available AS-OCT and/or a novel custom-built ultrahigh resolution (UHR) AS-OCT. Argon laser photocoagulation was also used to confirm epithelial ingrowth on the iris surface. Pathological evidence of epithelial ingrowth was noted in an eye that underwent corneoscleral grafting for extensive ingrowth through a fistulous tract. RESULTS:: Epithelial ingrowth was solely in the graft-host interface in 1 case and in both the interface and retrocorneal and iris surfaces in 4 cases. Argon laser photocoagulation on the iris confirmed epithelial ingrowth in 4 cases. The areas of epithelial ingrowth were imaged in 1 case with the Visante AS-OCT and in 3 cases with an UHR-OCT. In 1 case, block excision with corneoscleral grafting was required. CONCLUSIONS:: Epithelial ingrowth can occur after DSAEK. This series reports 5 cases of epithelial ingrowth into the interface and/or the retrocorneal surface after DSAEK. Imaging with AS-OCT, specifically the UHR-OCT, and argon laser photocoagulation can help confirm the diagnosis. UHR-OCT imaging of the interface and retrocorneal surfaces can provide clues to the origin of epithelial ingrowth. Four cases were observed. One case underwent corneoscleral grafting with histological confirmation of epithelial ingrowth.

KW - anterior segment optical coherence tomography

KW - Descemet stripping automated endothelial keratoplasty

KW - epithelial ingrowth

UR - http://www.scopus.com/inward/record.url?scp=79955069616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955069616&partnerID=8YFLogxK

U2 - 10.1097/ICO.0b013e3181fb8149

DO - 10.1097/ICO.0b013e3181fb8149

M3 - Article

VL - 30

SP - 528

EP - 534

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 5

ER -