Epithelial Downgrowth in the Vitreous Cavity and on the Retina in Enucleated Specimens and in Eyes with Visual Potential

Aleksandra V. Rachitskaya, Sander Dubovy, Rehan M. Hussain, Victor L Perez Quinones, Eduardo C Alfonso, Audina Berrocal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To report clinical course and visual and anatomical outcomes of six eyes with histopathologically confirmed vitreous cavity and retina epithelial downgrowth. Methods: This is a retrospective 15-year review of archived pathologic slides and corresponding medical records of patients with vitreous cavity and retina epithelial downgrowth. Posterior segment epithelial downgrowth was defined as epithelial or goblet cells in the vitreous cavity or on the surface of the retina. Results: Histopathologic diagnosis of epithelial downgrowth was made in 122 patients. Of those, 6 patients (5%) had vitreous cavity and retina epithelial downgrowth. Three patients developed blind painful eye, and epithelial downgrowth was identified in enucleated specimens. The other three eyes with visual potential presented with tractional retinal detachments. Epithelial downgrowth was identified in epiretinal membranes obtained during pars plana vitrectomy. The latter group had more previous surgeries (P 0.03), and all had keratoprosthesis implantation as their last surgery. All three had pathologic specimens obtained at the time of the keratoprosthesis implantation; no anterior segment epithelial downgrowth was noted in two patients, and one patient had involvement of corneal button, iris, and posterior capsule. Final visual acuity ranged from hand motion to light perception. Conclusion: In the current study, vitreous cavity and retina epithelial downgrowth occurred after multiple intraocular surgeries, including repair of the open globe injuries both in enucleated specimens and in eyes with visual potential. In eyes with visual potential, keratoprosthesis implantation seems to predispose the development of posterior segment epithelial downgrowth.

Original languageEnglish (US)
Pages (from-to)1688-1695
Number of pages8
JournalRetina
Volume35
Issue number8
DOIs
StatePublished - Aug 7 2015

Fingerprint

Retina
Epiretinal Membrane
Goblet Cells
Temazepam
Vitrectomy
Iris
Retinal Detachment
Visual Acuity
Capsules
Medical Records
Hand
Epithelial Cells
Light
Wounds and Injuries

Keywords

  • epithelial downgrowth
  • keratoprosthesis
  • retina
  • tractional retinal detachment
  • vitreous

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Epithelial Downgrowth in the Vitreous Cavity and on the Retina in Enucleated Specimens and in Eyes with Visual Potential. / Rachitskaya, Aleksandra V.; Dubovy, Sander; Hussain, Rehan M.; Perez Quinones, Victor L; Alfonso, Eduardo C; Berrocal, Audina.

In: Retina, Vol. 35, No. 8, 07.08.2015, p. 1688-1695.

Research output: Contribution to journalArticle

Rachitskaya, Aleksandra V. ; Dubovy, Sander ; Hussain, Rehan M. ; Perez Quinones, Victor L ; Alfonso, Eduardo C ; Berrocal, Audina. / Epithelial Downgrowth in the Vitreous Cavity and on the Retina in Enucleated Specimens and in Eyes with Visual Potential. In: Retina. 2015 ; Vol. 35, No. 8. pp. 1688-1695.
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