Epilepsy surgery in patients with normal or nonfocal MRI scans: Integrative strategies offer long-term seizure relief

Prasanna Jayakar, Catalina Dunoyer, Pat Dean, John Ragheb, Trevor Resnick, Glenn Morrison, Sanjiv Bhatia, Michael Duchowny

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Purpose: Excisional surgery achieves seizure freedom in a large proportion of children with intractable lesional epilepsy, but the outcome for children without a focal lesion on MRI is less clear. We report the outcome of a cohort predominantly of children with nonlesional intractable partial epilepsy undergoing resective surgery. Methods: We studied 102 patients with nonlesional intractable partial epilepsy who underwent excisional surgery. The epileptogenic region was identified by integrating clinical exam and video-EEG data complemented by ictal SPECT (n = 40), PET (n = 10), extraoperative subdural monitoring (n = 80), and electrocorticography (n = 22). All patients had follow-up greater than 2 years, 76 patients had 5-year follow-up, and 43 patients had 10-year follow-up. Results: A total of 66 resections were unilobar; 36 were multilobar. One patient died of causes unrelated to seizures or surgery. At 2-year follow-up, 44 of 101 patients were seizure-free, 15 experienced >90% reduction, 17 had >50% reduction, and 25 were unchanged. At 5-year follow-up, 35 of 76 patients were seizure-free, 12 experienced >90% reduction, 12 had >50% reduction, and 17 were unchanged. At 10-year follow-up, 16 of 43 patients were seizure-free, 13 experienced >90% reduction, 7 had >50% reduction, and 7 were unchanged. Outcomes correlated with the presence of convergent focal interictal spikes (p < 0.005) on the scalp EEG and completeness of resection (p < 0.0005). Conclusions: Our findings demonstrate that excisional surgery is successful in the majority of children with nonlesional partial epilepsy. A multimodal integrative approach can minimize the size of resection and alleviate the need for invasive EEG monitoring. Focal interictal spikes and completeness of resection predict good outcome. The benefits of surgery are long-lasting.

Original languageEnglish
Pages (from-to)758-764
Number of pages7
JournalEpilepsia
Volume49
Issue number5
DOIs
StatePublished - May 1 2008

Fingerprint

Epilepsy
Seizures
Magnetic Resonance Imaging
Partial Epilepsy
Electroencephalography
Single-Photon Emission-Computed Tomography
Scalp
Stroke
Drug Resistant Epilepsy

Keywords

  • Children
  • Complete resection
  • Epilepsy surgery
  • Integrated strategies
  • Long-term outcome
  • Normal MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Jayakar, P., Dunoyer, C., Dean, P., Ragheb, J., Resnick, T., Morrison, G., ... Duchowny, M. (2008). Epilepsy surgery in patients with normal or nonfocal MRI scans: Integrative strategies offer long-term seizure relief. Epilepsia, 49(5), 758-764. https://doi.org/10.1111/j.1528-1167.2007.01428.x

Epilepsy surgery in patients with normal or nonfocal MRI scans : Integrative strategies offer long-term seizure relief. / Jayakar, Prasanna; Dunoyer, Catalina; Dean, Pat; Ragheb, John; Resnick, Trevor; Morrison, Glenn; Bhatia, Sanjiv; Duchowny, Michael.

In: Epilepsia, Vol. 49, No. 5, 01.05.2008, p. 758-764.

Research output: Contribution to journalArticle

Jayakar, P, Dunoyer, C, Dean, P, Ragheb, J, Resnick, T, Morrison, G, Bhatia, S & Duchowny, M 2008, 'Epilepsy surgery in patients with normal or nonfocal MRI scans: Integrative strategies offer long-term seizure relief', Epilepsia, vol. 49, no. 5, pp. 758-764. https://doi.org/10.1111/j.1528-1167.2007.01428.x
Jayakar, Prasanna ; Dunoyer, Catalina ; Dean, Pat ; Ragheb, John ; Resnick, Trevor ; Morrison, Glenn ; Bhatia, Sanjiv ; Duchowny, Michael. / Epilepsy surgery in patients with normal or nonfocal MRI scans : Integrative strategies offer long-term seizure relief. In: Epilepsia. 2008 ; Vol. 49, No. 5. pp. 758-764.
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abstract = "Purpose: Excisional surgery achieves seizure freedom in a large proportion of children with intractable lesional epilepsy, but the outcome for children without a focal lesion on MRI is less clear. We report the outcome of a cohort predominantly of children with nonlesional intractable partial epilepsy undergoing resective surgery. Methods: We studied 102 patients with nonlesional intractable partial epilepsy who underwent excisional surgery. The epileptogenic region was identified by integrating clinical exam and video-EEG data complemented by ictal SPECT (n = 40), PET (n = 10), extraoperative subdural monitoring (n = 80), and electrocorticography (n = 22). All patients had follow-up greater than 2 years, 76 patients had 5-year follow-up, and 43 patients had 10-year follow-up. Results: A total of 66 resections were unilobar; 36 were multilobar. One patient died of causes unrelated to seizures or surgery. At 2-year follow-up, 44 of 101 patients were seizure-free, 15 experienced >90{\%} reduction, 17 had >50{\%} reduction, and 25 were unchanged. At 5-year follow-up, 35 of 76 patients were seizure-free, 12 experienced >90{\%} reduction, 12 had >50{\%} reduction, and 17 were unchanged. At 10-year follow-up, 16 of 43 patients were seizure-free, 13 experienced >90{\%} reduction, 7 had >50{\%} reduction, and 7 were unchanged. Outcomes correlated with the presence of convergent focal interictal spikes (p < 0.005) on the scalp EEG and completeness of resection (p < 0.0005). Conclusions: Our findings demonstrate that excisional surgery is successful in the majority of children with nonlesional partial epilepsy. A multimodal integrative approach can minimize the size of resection and alleviate the need for invasive EEG monitoring. Focal interictal spikes and completeness of resection predict good outcome. The benefits of surgery are long-lasting.",
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