Epilepsy; Drug Treatment Principles

R. H. Mattson, K. Detyniecki, P. Farooque

Research output: Chapter in Book/Report/Conference proceedingChapter


Antiepileptic drug selection is most dictated by the expectation that the drug will control or maximally prevent seizures. Evidence-based studies confirm that some drugs are superior for certain seizure types such as absence and myoclonic. Differences in efficacy for partial onset seizures are often modest, so the choice of drug may be decided by other factors such as expected adverse effects, comorbidities, pharmacokinetics, age, gender, and cost. No drug of choice exists for each seizure type. Rather careful individualized selection is indicated.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages5
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014
Externally publishedYes


  • Adverse effects
  • Age
  • Antiepileptic drug
  • Efficacy
  • Expense
  • Gender
  • Management
  • Pharmacokinetics
  • Selection factors

ASJC Scopus subject areas

  • Medicine(all)


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