Epigenetic targets in the diagnosis and treatment of prostate cancer

Murugesan Manoharan, Kavitha Ramachandran, Mark S. Soloway, Rakesh Singal

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Prostate cancer (PC) is one of leading cause of cancer related deaths in men. Various aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic changes including DNA methylation and histone modifications in prostate cancer is being studied widely. The epigenetic changes are early event in the cancer development and are reversible. Novel epigenetic markers are being studied, which have the potential as sensitive diagnostic and prognostic marker. Variety of drugs targeting epigenetic changes are being studied, which can be effective individually or in combination with other conventional drugs in PC treatment. In this review, we discuss epigenetic changes associated with PC and their potential diagnostic and therapeutic applications including future areas of research.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalInternational Braz J Urol
Volume33
Issue number1
StatePublished - Jan 1 2007

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Epigenomics
Prostatic Neoplasms
Therapeutics
Histone Code
Neoplasms
DNA Methylation
Drug Delivery Systems
Research
Pharmaceutical Preparations

Keywords

  • DNA methylation
  • Epigenesis
  • Genetic
  • Prostate cancer

ASJC Scopus subject areas

  • Nephrology

Cite this

Manoharan, M., Ramachandran, K., Soloway, M. S., & Singal, R. (2007). Epigenetic targets in the diagnosis and treatment of prostate cancer. International Braz J Urol, 33(1), 11-18.

Epigenetic targets in the diagnosis and treatment of prostate cancer. / Manoharan, Murugesan; Ramachandran, Kavitha; Soloway, Mark S.; Singal, Rakesh.

In: International Braz J Urol, Vol. 33, No. 1, 01.01.2007, p. 11-18.

Research output: Contribution to journalArticle

Manoharan, M, Ramachandran, K, Soloway, MS & Singal, R 2007, 'Epigenetic targets in the diagnosis and treatment of prostate cancer', International Braz J Urol, vol. 33, no. 1, pp. 11-18.
Manoharan, Murugesan ; Ramachandran, Kavitha ; Soloway, Mark S. ; Singal, Rakesh. / Epigenetic targets in the diagnosis and treatment of prostate cancer. In: International Braz J Urol. 2007 ; Vol. 33, No. 1. pp. 11-18.
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