Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Bryce K. Allen, Vasileios Stathias, Marie E. Maloof, Dusica Vidovic, Emily F. Winterbottom, Anthony J Capobianco, Jennifer Clarke, Stephan C Schuerer, David J Robbins, Nagi Ayad

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

There is an urgent need to identify novel therapies for glioblastoma (GBM) as most therapies are ineffective. A first step in this process is to identify and validate targets for therapeutic intervention. Epigenetic modulators have emerged as attractive drug targets in several cancers including GBM. These epigenetic regulators affect gene expression without changing the DNA sequence. Recent studies suggest that epigenetic regulators interact with drivers of GBM cell and stem-like cell proliferation. These drivers include components of the Notch, Hedgehog, and Wingless (WNT) pathways. We highlight recent studies connecting epigenetic and signaling pathways in GBM. We also review systems and big data approaches for identifying patient specific therapies in GBM. Collectively, these studies will identify drug combinations that may be effective in GBM and other cancers. J. Cell. Biochem. 116: 351-363, 2015.

Original languageEnglish (US)
Pages (from-to)351-363
Number of pages13
JournalJournal of Cellular Biochemistry
Volume116
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • EPIGENETICS
  • GLIOBLASTOMA
  • HEDGEHOG
  • NOTCH
  • SIGNALING PATHWAYS
  • WINGLESS

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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