Abstract
The process of spermatogenesis is a unique form of cellular differentiation and is regulated by genetic and epigenetic factors. Recent studies have shown that some epigenetic factors (histone variants and histone modifying enzymes) are exclusively expressed during spermatogenesis; the disruption of these factors leads to spermatogenic defects. Also, during spermatogenesis a key epigenetic process termed meiotic sex chromosome inactivation (MSCI) occurs; MSCI leads to the inactivation of most genes on the X and Y chromosomes; however, the mechanism of MSCI is distinct from X inactivation in female somatic cells. Furthermore, a new class of non-coding RNAs (i.e., piRNAs) has recently been identified which is exclusively expressed during spermatogenesis. This review discusses recent advances in our understanding of epigenetic mechanisms that operate during spermatogenesis with specific emphasis on histone modifications, MSCI and non-coding RNAs. Finally, we propose that spermatogenesis can be a powerful experimental system to dissect epigenetic mechanisms of gene regulation.
| Original language | English |
|---|---|
| Pages (from-to) | 21-27 |
| Number of pages | 7 |
| Journal | Epigenetics |
| Volume | 3 |
| Issue number | 1 |
| State | Published - Jan 1 2008 |
| Externally published | Yes |
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Keywords
- Epigenetics
- Histone modifications
- Meiosis
- MSCI
- Non-coding RNAs
- Spermatogenesis
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
Cite this
Epigenetic mechanisms of gene regulation during mammalian spermatogenesis. / Khalil, Ahmad M.; Wahlestedt, Claes R.
In: Epigenetics, Vol. 3, No. 1, 01.01.2008, p. 21-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epigenetic mechanisms of gene regulation during mammalian spermatogenesis
AU - Khalil, Ahmad M.
AU - Wahlestedt, Claes R
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The process of spermatogenesis is a unique form of cellular differentiation and is regulated by genetic and epigenetic factors. Recent studies have shown that some epigenetic factors (histone variants and histone modifying enzymes) are exclusively expressed during spermatogenesis; the disruption of these factors leads to spermatogenic defects. Also, during spermatogenesis a key epigenetic process termed meiotic sex chromosome inactivation (MSCI) occurs; MSCI leads to the inactivation of most genes on the X and Y chromosomes; however, the mechanism of MSCI is distinct from X inactivation in female somatic cells. Furthermore, a new class of non-coding RNAs (i.e., piRNAs) has recently been identified which is exclusively expressed during spermatogenesis. This review discusses recent advances in our understanding of epigenetic mechanisms that operate during spermatogenesis with specific emphasis on histone modifications, MSCI and non-coding RNAs. Finally, we propose that spermatogenesis can be a powerful experimental system to dissect epigenetic mechanisms of gene regulation.
AB - The process of spermatogenesis is a unique form of cellular differentiation and is regulated by genetic and epigenetic factors. Recent studies have shown that some epigenetic factors (histone variants and histone modifying enzymes) are exclusively expressed during spermatogenesis; the disruption of these factors leads to spermatogenic defects. Also, during spermatogenesis a key epigenetic process termed meiotic sex chromosome inactivation (MSCI) occurs; MSCI leads to the inactivation of most genes on the X and Y chromosomes; however, the mechanism of MSCI is distinct from X inactivation in female somatic cells. Furthermore, a new class of non-coding RNAs (i.e., piRNAs) has recently been identified which is exclusively expressed during spermatogenesis. This review discusses recent advances in our understanding of epigenetic mechanisms that operate during spermatogenesis with specific emphasis on histone modifications, MSCI and non-coding RNAs. Finally, we propose that spermatogenesis can be a powerful experimental system to dissect epigenetic mechanisms of gene regulation.
KW - Epigenetics
KW - Histone modifications
KW - Meiosis
KW - MSCI
KW - Non-coding RNAs
KW - Spermatogenesis
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UR - http://www.scopus.com/inward/citedby.url?scp=42149084976&partnerID=8YFLogxK
M3 - Article
C2 - 18416029
AN - SCOPUS:42149084976
VL - 3
SP - 21
EP - 27
JO - Epigenetics
JF - Epigenetics
SN - 1559-2294
IS - 1
ER -