Epigenetic changes in prostatic tissues: Evidence of field cancerization

Devendar Katkoori, Rakesh Singal, Murugesan Manoharan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Prostate cancer (PC) alone accounts for 25% of incident cases of cancer in men and is the most frequently diagnosed cancer in American men. Early diagnosis is essential for successful management of PC. Current diagnostic methods have significant drawbacks leading to a significant dilemma in selecting the appropriate management strategy. The need for improving both the diagnostic accuracy and prognostic prediction is evident. There is overwhelming evidence to support the view that epigenetic markers in PC can have diagnostic, therapeutic and prognostic implications. Two of the well-studied epigenetic mechanisms are aberrant DNA methylation and histone modifications. The identification of specific genetic alterations can help in both establishing a diagnosis and also provide useful prognostic information. It is also exciting to know that epigenetic changes are heritable and potentially reversible. Hence, it is reasonable to expect that these can be used as potential therapeutic targets. Currently there are several drugs that are at different stages of development. More recent evidence has focused on a field cancer effect in PC. Epigenetic changes as evidence to this field cancerization have important clinical implications in chemoprevention, early diagnosis, prognostic prediction and active surveillance.

Original languageEnglish (US)
Title of host publicationField Cancerization
Subtitle of host publicationBasic Science and Clinical Applications
PublisherNova Science Publishers, Inc.
Pages447-460
Number of pages14
ISBN (Print)9781617610066
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Katkoori, D., Singal, R., & Manoharan, M. (2011). Epigenetic changes in prostatic tissues: Evidence of field cancerization. In Field Cancerization: Basic Science and Clinical Applications (pp. 447-460). Nova Science Publishers, Inc..