Abstract
Prostate cancer (PC) alone accounts for 25% of incident cases of cancer in men and is the most frequently diagnosed cancer in American men. Early diagnosis is essential for successful management of PC. Current diagnostic methods have significant drawbacks leading to a significant dilemma in selecting the appropriate management strategy. The need for improving both the diagnostic accuracy and prognostic prediction is evident. There is overwhelming evidence to support the view that epigenetic markers in PC can have diagnostic, therapeutic and prognostic implications. Two of the well-studied epigenetic mechanisms are aberrant DNA methylation and histone modifications. The identification of specific genetic alterations can help in both establishing a diagnosis and also provide useful prognostic information. It is also exciting to know that epigenetic changes are heritable and potentially reversible. Hence, it is reasonable to expect that these can be used as potential therapeutic targets. Currently there are several drugs that are at different stages of development. More recent evidence has focused on a field cancer effect in PC. Epigenetic changes as evidence to this field cancerization have important clinical implications in chemoprevention, early diagnosis, prognostic prediction and active surveillance.
| Original language | English |
|---|---|
| Title of host publication | Field Cancerization: Basic Science and Clinical Applications |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 447-460 |
| Number of pages | 14 |
| ISBN (Print) | 9781617610066 |
| State | Published - Dec 1 2011 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Epigenetic changes in prostatic tissues : Evidence of field cancerization. / Katkoori, Devendar; Singal, Rakesh; Manoharan, Murugesan.
Field Cancerization: Basic Science and Clinical Applications. Nova Science Publishers, Inc., 2011. p. 447-460.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Epigenetic changes in prostatic tissues
T2 - Evidence of field cancerization
AU - Katkoori, Devendar
AU - Singal, Rakesh
AU - Manoharan, Murugesan
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Prostate cancer (PC) alone accounts for 25% of incident cases of cancer in men and is the most frequently diagnosed cancer in American men. Early diagnosis is essential for successful management of PC. Current diagnostic methods have significant drawbacks leading to a significant dilemma in selecting the appropriate management strategy. The need for improving both the diagnostic accuracy and prognostic prediction is evident. There is overwhelming evidence to support the view that epigenetic markers in PC can have diagnostic, therapeutic and prognostic implications. Two of the well-studied epigenetic mechanisms are aberrant DNA methylation and histone modifications. The identification of specific genetic alterations can help in both establishing a diagnosis and also provide useful prognostic information. It is also exciting to know that epigenetic changes are heritable and potentially reversible. Hence, it is reasonable to expect that these can be used as potential therapeutic targets. Currently there are several drugs that are at different stages of development. More recent evidence has focused on a field cancer effect in PC. Epigenetic changes as evidence to this field cancerization have important clinical implications in chemoprevention, early diagnosis, prognostic prediction and active surveillance.
AB - Prostate cancer (PC) alone accounts for 25% of incident cases of cancer in men and is the most frequently diagnosed cancer in American men. Early diagnosis is essential for successful management of PC. Current diagnostic methods have significant drawbacks leading to a significant dilemma in selecting the appropriate management strategy. The need for improving both the diagnostic accuracy and prognostic prediction is evident. There is overwhelming evidence to support the view that epigenetic markers in PC can have diagnostic, therapeutic and prognostic implications. Two of the well-studied epigenetic mechanisms are aberrant DNA methylation and histone modifications. The identification of specific genetic alterations can help in both establishing a diagnosis and also provide useful prognostic information. It is also exciting to know that epigenetic changes are heritable and potentially reversible. Hence, it is reasonable to expect that these can be used as potential therapeutic targets. Currently there are several drugs that are at different stages of development. More recent evidence has focused on a field cancer effect in PC. Epigenetic changes as evidence to this field cancerization have important clinical implications in chemoprevention, early diagnosis, prognostic prediction and active surveillance.
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UR - http://www.scopus.com/inward/citedby.url?scp=84895327200&partnerID=8YFLogxK
M3 - Chapter
SN - 9781617610066
SP - 447
EP - 460
BT - Field Cancerization: Basic Science and Clinical Applications
PB - Nova Science Publishers, Inc.
ER -