Epigenetic aspects of cellular senescence

Juan Young, James R. Smith

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalExperimental Gerontology
Issue number1
StatePublished - Feb 2000
Externally publishedYes


  • Aging
  • Cell cycle
  • p16
  • p21
  • Reactive oxygen species

ASJC Scopus subject areas

  • Aging
  • Medicine(all)


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