Epigenetic aspects of cellular senescence

Juan Young; James R. Smith

doi:10.1016/S0531-5565(99)00076-5

Epigenetic aspects of cellular senescence

Juan Young, James R. Smith

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	23-32
Number of pages	10
Journal	Experimental Gerontology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/S0531-5565(99)00076-5
State	Published - Feb 2000
Externally published	Yes

Keywords

Aging
Cell cycle
p16
p21
Reactive oxygen species

ASJC Scopus subject areas

Aging
Medicine(all)

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title = "Epigenetic aspects of cellular senescence",

abstract = "The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.",

keywords = "Aging, Cell cycle, p16, p21, Reactive oxygen species",

author = "Juan Young and Smith, {James R.}",

note = "Funding Information: This work was supported by NIA grant P01 AG13663 to J. R. S. and the Francisco Macri Fellowship from the Macri Foundation to J. Y. ",

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AU - Young, Juan

AU - Smith, James R.

N1 - Funding Information: This work was supported by NIA grant P01 AG13663 to J. R. S. and the Francisco Macri Fellowship from the Macri Foundation to J. Y.

PY - 2000/2

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N2 - The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.

AB - The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.

KW - Aging

KW - Cell cycle

KW - p16

KW - p21

KW - Reactive oxygen species

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JO - Experimental Gerontology

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Epigenetic aspects of cellular senescence

Abstract

Keywords

ASJC Scopus subject areas

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