Abstract
The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23-32 |
| Number of pages | 10 |
| Journal | Experimental Gerontology |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2000 |
| Externally published | Yes |
Keywords
- Aging
- Cell cycle
- p16
- p21
- Reactive oxygen species
ASJC Scopus subject areas
- Aging
- Medicine(all)