Abstract
The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 23-32 |
| Number of pages | 10 |
| Journal | Experimental Gerontology |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2000 |
| Externally published | Yes |
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Keywords
- Aging
- Cell cycle
- p16
- p21
- Reactive oxygen species
ASJC Scopus subject areas
- Aging
- Medicine(all)
Cite this
Epigenetic aspects of cellular senescence. / Young, Juan; Smith, James R.
In: Experimental Gerontology, Vol. 35, No. 1, 01.02.2000, p. 23-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epigenetic aspects of cellular senescence
AU - Young, Juan
AU - Smith, James R.
PY - 2000/2/1
Y1 - 2000/2/1
N2 - The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.
AB - The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.
KW - Aging
KW - Cell cycle
KW - p16
KW - p21
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=0034141896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034141896&partnerID=8YFLogxK
U2 - 10.1016/S0531-5565(99)00076-5
DO - 10.1016/S0531-5565(99)00076-5
M3 - Article
C2 - 10705036
AN - SCOPUS:0034141896
VL - 35
SP - 23
EP - 32
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 1
ER -