Epigenetic aspects of cellular senescence

Juan Young, James R. Smith

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalExperimental Gerontology
Volume35
Issue number1
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

Fingerprint

Cell Aging
Epigenomics
Aging of materials
Genetic Epigenesis
Cell Culture Techniques
Cell Count
Experiments

Keywords

  • Aging
  • Cell cycle
  • p16
  • p21
  • Reactive oxygen species

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

Epigenetic aspects of cellular senescence. / Young, Juan; Smith, James R.

In: Experimental Gerontology, Vol. 35, No. 1, 01.02.2000, p. 23-32.

Research output: Contribution to journalArticle

Young, Juan ; Smith, James R. / Epigenetic aspects of cellular senescence. In: Experimental Gerontology. 2000 ; Vol. 35, No. 1. pp. 23-32.
@article{fa5d7dd600194814b46a434eafb77501,
title = "Epigenetic aspects of cellular senescence",
abstract = "The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "Aging, Cell cycle, p16, p21, Reactive oxygen species",
author = "Juan Young and Smith, {James R.}",
year = "2000",
month = "2",
day = "1",
doi = "10.1016/S0531-5565(99)00076-5",
language = "English",
volume = "35",
pages = "23--32",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Epigenetic aspects of cellular senescence

AU - Young, Juan

AU - Smith, James R.

PY - 2000/2/1

Y1 - 2000/2/1

N2 - The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.

AB - The limited proliferative potential of normal cells in culture has been proposed as a model for cellular aging in vivo. It is clear that cellular aging has a genetic component but epigenetic processes could also be involved. Insight gained during years of intensive study suggests cellular aging is a multi-step process and that cells possess a counting mechanism that determines the number of doublings the cells can complete. In this paper, we review evidence suggesting a role for epigenetic processes in cell senescence and discuss the possible insights that might be provided by experiments designed to induce a premature senescent like state. Copyright (C) 2000 Elsevier Science Inc.

KW - Aging

KW - Cell cycle

KW - p16

KW - p21

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=0034141896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034141896&partnerID=8YFLogxK

U2 - 10.1016/S0531-5565(99)00076-5

DO - 10.1016/S0531-5565(99)00076-5

M3 - Article

C2 - 10705036

AN - SCOPUS:0034141896

VL - 35

SP - 23

EP - 32

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

IS - 1

ER -