Epidermal stem cells: The cradle of epidermal determination, differentiation and wound healing

Maria I. Morasso, Marjana Tomic-Canic

Research output: Contribution to journalReview article

144 Scopus citations

Abstract

The field of epidermal stem cells has dramatically advanced in the last decade, leading to a better understanding of the molecular factors, signalling pathways and cellular events that identify and characterize stem cells, thus revealing their immense potential for therapeutic use. Furthermore, multipotent epidermal stem cells present the major advantage of easy accessibility with the discovery of their specific location within the bulge of the hair follicle. This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin.

Original languageEnglish (US)
Pages (from-to)173-183
Number of pages11
JournalBiology of the Cell
Volume97
Issue number3
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

Keywords

  • Differentiation
  • Epidermis
  • Hair follicle
  • Stem cell
  • Wound healing

ASJC Scopus subject areas

  • Cell Biology

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