Epidermal stem cells: The cradle of epidermal determination, differentiation and wound healing

Maria I. Morasso; Marjana Tomic-Canic

doi:10.1042/BC20040098

Epidermal stem cells: The cradle of epidermal determination, differentiation and wound healing

Maria I. Morasso, Marjana Tomic-Canic

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

The field of epidermal stem cells has dramatically advanced in the last decade, leading to a better understanding of the molecular factors, signalling pathways and cellular events that identify and characterize stem cells, thus revealing their immense potential for therapeutic use. Furthermore, multipotent epidermal stem cells present the major advantage of easy accessibility with the discovery of their specific location within the bulge of the hair follicle. This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin.

Original language	English (US)
Pages (from-to)	173-183
Number of pages	11
Journal	Biology of the Cell
Volume	97
Issue number	3
DOIs	https://doi.org/10.1042/BC20040098
State	Published - Mar 2005
Externally published	Yes

Keywords

Differentiation
Epidermis
Hair follicle
Stem cell
Wound healing

ASJC Scopus subject areas

Cell Biology

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10.1042/BC20040098

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AB - The field of epidermal stem cells has dramatically advanced in the last decade, leading to a better understanding of the molecular factors, signalling pathways and cellular events that identify and characterize stem cells, thus revealing their immense potential for therapeutic use. Furthermore, multipotent epidermal stem cells present the major advantage of easy accessibility with the discovery of their specific location within the bulge of the hair follicle. This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin.

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