Abstract
Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. Methods: Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease. Results: The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively]. Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide. Copyrigt
| Original language | English |
|---|---|
| Pages (from-to) | 1354-1358 |
| Number of pages | 5 |
| Journal | Cornea |
| Volume | 32 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2013 |
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Keywords
- Epidemiology
- Ocular surface squamous neoplasia
- Pterygium
- Sun-related neoplasias
ASJC Scopus subject areas
- Ophthalmology
Cite this
Epidemiology of ocular surface squamous neoplasia in a veterans affairs population. / McClellan, Andrew J.; McClellan, Allison L.; Pezon, Candido F.; Karp, Carol; Feuer, William J; Galor, Anat.
In: Cornea, Vol. 32, No. 10, 01.10.2013, p. 1354-1358.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epidemiology of ocular surface squamous neoplasia in a veterans affairs population
AU - McClellan, Andrew J.
AU - McClellan, Allison L.
AU - Pezon, Candido F.
AU - Karp, Carol
AU - Feuer, William J
AU - Galor, Anat
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. Methods: Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease. Results: The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively]. Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide. Copyrigt
AB - Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. Methods: Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease. Results: The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively]. Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide. Copyrigt
KW - Epidemiology
KW - Ocular surface squamous neoplasia
KW - Pterygium
KW - Sun-related neoplasias
UR - http://www.scopus.com/inward/record.url?scp=84886084720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886084720&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e31829e3c80
DO - 10.1097/ICO.0b013e31829e3c80
M3 - Article
C2 - 23974890
AN - SCOPUS:84886084720
VL - 32
SP - 1354
EP - 1358
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - 10
ER -