Epidemiology of ocular surface squamous neoplasia in a veterans affairs population

Andrew J. McClellan, Allison L. McClellan, Candido F. Pezon, Carol Karp, William J Feuer, Anat Galor

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. Methods: Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease. Results: The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively]. Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide. Copyrigt

Original languageEnglish
Pages (from-to)1354-1358
Number of pages5
JournalCornea
Volume32
Issue number10
DOIs
StatePublished - Oct 1 2013

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Veterans
Epidemiology
Population
Neoplasms
International Classification of Diseases
Pterygium
Papillomaviridae
Basal Cell Neoplasms
Odds Ratio
Confidence Intervals
HIV Seropositivity
Actinic Keratosis
Delivery of Health Care
Veterans Hospitals
Squamous Cell Neoplasms
United States Department of Veterans Affairs
Basal Cell Carcinoma
Tobacco Use
Solar System
Virus Diseases

Keywords

  • Epidemiology
  • Ocular surface squamous neoplasia
  • Pterygium
  • Sun-related neoplasias

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Epidemiology of ocular surface squamous neoplasia in a veterans affairs population. / McClellan, Andrew J.; McClellan, Allison L.; Pezon, Candido F.; Karp, Carol; Feuer, William J; Galor, Anat.

In: Cornea, Vol. 32, No. 10, 01.10.2013, p. 1354-1358.

Research output: Contribution to journalArticle

McClellan, Andrew J. ; McClellan, Allison L. ; Pezon, Candido F. ; Karp, Carol ; Feuer, William J ; Galor, Anat. / Epidemiology of ocular surface squamous neoplasia in a veterans affairs population. In: Cornea. 2013 ; Vol. 32, No. 10. pp. 1354-1358.
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N2 - Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. Methods: Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease. Results: The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively]. Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide. Copyrigt

AB - Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population. Methods: Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease. Results: The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively]. Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide. Copyrigt

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