Epidemiology of Comorbid Conditions Among Adults 50 Years and Older With Traumatic Brain Injury

Raj G. Kumar, Shannon B. Juengst, Zhensheng Wang, Kristen Dams-OʼConnor, Sureyya S. Dikmen, Therese M. OʼNeil-Pirozzi, Marie N. Dahdah, Flora M. Hammond, Elizabeth Felix, Patricia M. Arenth, Amy K. Wagner

Research output: Contribution to journalArticle

12 Scopus citations


OBJECTIVES:: Aging individuals with traumatic brain injury (TBI) experience multiple comorbidities that can affect recovery from injury. The objective of this study was to describe the most commonly co-occurring comorbid conditions among adults 50 years and older with TBI. SETTING:: Level I Trauma centers. PARTICIPANTS:: Adults 50 years and older with moderate/severe TBI enrolled in the TBI-Model Systems (TBI-MS) from 2007 to 2014 (n = 2134). DESIGN:: A TBI-MS prospective cohort study. MAIN MEASURES:: International Classification of Disease–9th Revision codes collapsed into 45 comorbidity categories. Comorbidity prevalence estimates and trend analyses were conducted by age strata (50-54, 55-64, 65-74, 75-84, ≥85 years). A dimension reduction method, Treelet Transform, classified clusters of comorbidities that tended to co-occur. RESULTS:: The 3 most commonly occurring comorbid categories were hypertensive disease (52.6/100 persons), other diseases of the respiratory system (51.8/100 persons), and fluid component imbalances (43.7/100 persons). Treelet Transform classified 3 clusters of comorbid codes, broadly classified as (1) acute medical diseases/infections, (2) chronic conditions, and (3) substance abuse disorders. CONCLUSION:: This study provides valuable insight into comorbid conditions that co-occur among adults 50 years and older with TBI and provides a foundation for future studies to explore how specific comorbidities affect TBI recovery.

Original languageEnglish (US)
JournalJournal of Head Trauma Rehabilitation
StateAccepted/In press - Jan 5 2017


ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Clinical Neurology

Cite this

Kumar, R. G., Juengst, S. B., Wang, Z., Dams-OʼConnor, K., Dikmen, S. S., OʼNeil-Pirozzi, T. M., Dahdah, M. N., Hammond, F. M., Felix, E., Arenth, P. M., & Wagner, A. K. (Accepted/In press). Epidemiology of Comorbid Conditions Among Adults 50 Years and Older With Traumatic Brain Injury. Journal of Head Trauma Rehabilitation. https://doi.org/10.1097/HTR.0000000000000273