Epidemiology and natural history of arteriovenous malformations.

C. Stapf, J. P. Mohr, J. Pile-Spellman, R. A. Solomon, Ralph L Sacco, E. S. Connolly

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The epidemiology and natural history of cerebral arteriovenous malformations (AVMs) remains incompletely elucidated. Several factors are responsible. With regard to the incidence and prevalence of AVMs, the results of prior studies have suffered because of the retrospective design, the use of nonspecific ICD-9 codes, and a focus on small genetically isolated populations. Recent data from the New York Islands AVM Hemorrhage Study, an ongoing, prospective, population-based survey determining the incidence of AVM-related hemorrhage and the associated rates of morbidity and mortality in a zip code-defined population of 10 million people, suggests that the AVM detection rate is 1.21/100,000 person-years (95% confidence interval [CI] 1.02-1.42) and the incidence of AVM-hemorrhage is 0.42/100,000 person-years (95% CI 0.32-0.55). Contemporaneous data from the Northern Manhattan Stroke Study, a prospective, longitudinal population-based study of nearly 150,000 patients in which the focus is to define the incidence of stroke, suggest the crude incidence for first-ever AVM-related hemorrhage to be 0.55/100,000 person-years (95% CI 0.11-1.61). Efforts are ongoing to study the natural history of both ruptured and unruptured AVMs in these datasets to examine the relevance of prior studies of patients selected for conservative follow up in Finland. In addition, data are being gathered to determine whether risk factors for future hemorrhage, which have previously been established in small case series, are valid when applied to whole populations. Together, these data should help inform therapeutic decisionmaking.

Original languageEnglish
JournalNeurosurgical focus [electronic resource].
Volume11
Issue number5
StatePublished - Dec 1 2001
Externally publishedYes

Fingerprint

Arteriovenous Malformations
Epidemiology
Hemorrhage
Incidence
Population
International Classification of Diseases
Confidence Intervals
Stroke
Prospective Studies
Intracranial Arteriovenous Malformations
Finland
Natural History
Islands
Morbidity
Mortality

Cite this

Stapf, C., Mohr, J. P., Pile-Spellman, J., Solomon, R. A., Sacco, R. L., & Connolly, E. S. (2001). Epidemiology and natural history of arteriovenous malformations. Neurosurgical focus [electronic resource]., 11(5).

Epidemiology and natural history of arteriovenous malformations. / Stapf, C.; Mohr, J. P.; Pile-Spellman, J.; Solomon, R. A.; Sacco, Ralph L; Connolly, E. S.

In: Neurosurgical focus [electronic resource]., Vol. 11, No. 5, 01.12.2001.

Research output: Contribution to journalArticle

Stapf, C, Mohr, JP, Pile-Spellman, J, Solomon, RA, Sacco, RL & Connolly, ES 2001, 'Epidemiology and natural history of arteriovenous malformations.', Neurosurgical focus [electronic resource]., vol. 11, no. 5.
Stapf C, Mohr JP, Pile-Spellman J, Solomon RA, Sacco RL, Connolly ES. Epidemiology and natural history of arteriovenous malformations. Neurosurgical focus [electronic resource]. 2001 Dec 1;11(5).
Stapf, C. ; Mohr, J. P. ; Pile-Spellman, J. ; Solomon, R. A. ; Sacco, Ralph L ; Connolly, E. S. / Epidemiology and natural history of arteriovenous malformations. In: Neurosurgical focus [electronic resource]. 2001 ; Vol. 11, No. 5.
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