Background: The long-term course of human immunodeficiency virus type 1 (HIV-1)-related disease among seropositive blood donors has not been described. The enrollment and epidemiologic background of HIV-1-infected donors in the Transfusion Safety Study and their immunologic and clinical progression are described. Study Design and Methods: Through the testing of approximately 200,000 sera from donations made in late 1984 and early 1985, 146 anti-HIV-1-positive donors and 151 uninfected matched donors were enrolled. These two cohorts were followed with 6-month interval histories and laboratory testing. Results: Seropositive donors detected before the institution of routine anti-HIV-1 screening disproportionately were first- time donors and men with exclusively male sexual contacts. The actuarial probability of a person's developing AIDS within 7 years after donation was 40 percent; the probability of a person's dying of AIDS was 28 percent. AIDS developed more often when the donor was p24 antigen-positive at donation. Over a 3-year period, significant decreases occurred in CD4+, CD2+CD26+, CD4+CD29+, and CD20+CD21+ counts, but not in CD8+ subsets, CD20+, or CD14+. Conclusion: The high proportions of first-time donations and exclusively homosexual men among seropositive donors suggest that test- seeking may have contributed to the high HIV-1 prevalence in the repository. Implementation of alternative test sites when routine donor screening began in 1985 may have averted many high-risk donations. The disease course in HIV- 1-infected donors had the same wide spectrum of immunologic and clinical manifestations as were reported for other cohorts.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Oct 1994|
ASJC Scopus subject areas
- Immunology and Allergy