Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease

Antonio Concistrè, Luigi Petramala, Gianmarco Scoccia, Susanna Sciomer, Valeria Bisogni, Vincenza Saracino, Gino Iannucci, Silvia Lai, Daniela Mastroluca, Gianluca Iacobellis, Claudio Letizia

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2 Citations (Scopus)

Abstract

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown. Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Methods: We performed ultrasound measurement of EAT thickness, LVM, LVMi, and left atrium size (left atrial volume indexed for body surface, LAVI) in 41 consecutive hypertensive patients with ADPKD, compared to 89 EH patients. Results: EAT was significantly higher in the ADPKD group in comparison to EH subjects (9.2 ± 2.9 mm vs. 7.8 ± 1.6 mm, p < 0.001), and significantly correlated with LVM, LVMi, and LAVI in the ADPKD group (r = 0.56, p = 0.005; r = 0.424, p = 0.022; and r = 0.48, p = < 0.001, respectively). Comparing EAT against body mass index, systolic blood pressure, and age, we found that EAT was the strongest predictor of LVMi (β = 0.42, p = 0.007). Conclusion: Our data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalCardioRenal Medicine
DOIs
StateAccepted/In press - May 3 2018

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Autosomal Dominant Polycystic Kidney
Adipose Tissue
Fats
Blood Pressure
Body Surface Area
Left Ventricular Hypertrophy
Heart Atria
Body Mass Index
Essential Hypertension

Keywords

  • Autosomal dominant polycystic kidney disease
  • Cardiovascular disease
  • Epicardial fat thickness
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Urology

Cite this

Concistrè, A., Petramala, L., Scoccia, G., Sciomer, S., Bisogni, V., Saracino, V., ... Letizia, C. (Accepted/In press). Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease. CardioRenal Medicine, 199-207. https://doi.org/10.1159/000488064

Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease. / Concistrè, Antonio; Petramala, Luigi; Scoccia, Gianmarco; Sciomer, Susanna; Bisogni, Valeria; Saracino, Vincenza; Iannucci, Gino; Lai, Silvia; Mastroluca, Daniela; Iacobellis, Gianluca; Letizia, Claudio.

In: CardioRenal Medicine, 03.05.2018, p. 199-207.

Research output: Contribution to journalArticle

Concistrè, A, Petramala, L, Scoccia, G, Sciomer, S, Bisogni, V, Saracino, V, Iannucci, G, Lai, S, Mastroluca, D, Iacobellis, G & Letizia, C 2018, 'Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease', CardioRenal Medicine, pp. 199-207. https://doi.org/10.1159/000488064
Concistrè A, Petramala L, Scoccia G, Sciomer S, Bisogni V, Saracino V et al. Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease. CardioRenal Medicine. 2018 May 3;199-207. https://doi.org/10.1159/000488064
Concistrè, Antonio ; Petramala, Luigi ; Scoccia, Gianmarco ; Sciomer, Susanna ; Bisogni, Valeria ; Saracino, Vincenza ; Iannucci, Gino ; Lai, Silvia ; Mastroluca, Daniela ; Iacobellis, Gianluca ; Letizia, Claudio. / Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease. In: CardioRenal Medicine. 2018 ; pp. 199-207.
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abstract = "Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown. Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Methods: We performed ultrasound measurement of EAT thickness, LVM, LVMi, and left atrium size (left atrial volume indexed for body surface, LAVI) in 41 consecutive hypertensive patients with ADPKD, compared to 89 EH patients. Results: EAT was significantly higher in the ADPKD group in comparison to EH subjects (9.2 ± 2.9 mm vs. 7.8 ± 1.6 mm, p < 0.001), and significantly correlated with LVM, LVMi, and LAVI in the ADPKD group (r = 0.56, p = 0.005; r = 0.424, p = 0.022; and r = 0.48, p = < 0.001, respectively). Comparing EAT against body mass index, systolic blood pressure, and age, we found that EAT was the strongest predictor of LVMi (β = 0.42, p = 0.007). Conclusion: Our data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.",
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AU - Concistrè, Antonio

AU - Petramala, Luigi

AU - Scoccia, Gianmarco

AU - Sciomer, Susanna

AU - Bisogni, Valeria

AU - Saracino, Vincenza

AU - Iannucci, Gino

AU - Lai, Silvia

AU - Mastroluca, Daniela

AU - Iacobellis, Gianluca

AU - Letizia, Claudio

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N2 - Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown. Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Methods: We performed ultrasound measurement of EAT thickness, LVM, LVMi, and left atrium size (left atrial volume indexed for body surface, LAVI) in 41 consecutive hypertensive patients with ADPKD, compared to 89 EH patients. Results: EAT was significantly higher in the ADPKD group in comparison to EH subjects (9.2 ± 2.9 mm vs. 7.8 ± 1.6 mm, p < 0.001), and significantly correlated with LVM, LVMi, and LAVI in the ADPKD group (r = 0.56, p = 0.005; r = 0.424, p = 0.022; and r = 0.48, p = < 0.001, respectively). Comparing EAT against body mass index, systolic blood pressure, and age, we found that EAT was the strongest predictor of LVMi (β = 0.42, p = 0.007). Conclusion: Our data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.

AB - Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown. Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Methods: We performed ultrasound measurement of EAT thickness, LVM, LVMi, and left atrium size (left atrial volume indexed for body surface, LAVI) in 41 consecutive hypertensive patients with ADPKD, compared to 89 EH patients. Results: EAT was significantly higher in the ADPKD group in comparison to EH subjects (9.2 ± 2.9 mm vs. 7.8 ± 1.6 mm, p < 0.001), and significantly correlated with LVM, LVMi, and LAVI in the ADPKD group (r = 0.56, p = 0.005; r = 0.424, p = 0.022; and r = 0.48, p = < 0.001, respectively). Comparing EAT against body mass index, systolic blood pressure, and age, we found that EAT was the strongest predictor of LVMi (β = 0.42, p = 0.007). Conclusion: Our data showed that EAT was higher in ADPKD patients than in EH subjects and independently correlated with LVMi. EAT measurement can be a useful marker for the cardiovascular risk stratification in ADPKD.

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KW - Epicardial fat thickness

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