Epicardial fat thickness correlates with carotid intima-media thickness, arterial stiffness, and cardiac geometry in children and adolescents

Julio Oscar Cabrera-Rego, Gianluca Iacobellis, José Arcides Castillo-Herrera, Juan Valiente-Mustelier, Julio C. Gandarilla-Sarmientos, Silvia María Marín-Juliá, Juliette Navarrete-Cabrera

Research output: Contribution to journalArticle

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Abstract

To determine the association between epicardial fat thickness and carotid arterial stiffness, carotid intima-media thickness (CMIT), left atrial (LA) volume, and left-ventricular (LV) geometry parameters in obese children and adolescents compared with controls. A case-control study was performed in 96 children and adolescents (obese n = 66, controls n = 30) age 9-16 years old (38 female and 58 male, mean age 11.7 ± 2.8 years) undergoing transthoracic echocardiography and carotid artery ultrasound. Clinical, anthropometric, and biochemical determinations were also recorded. Epicardial fat thickness (2.76 ± 1.2 vs. 1.36 ± 0.7 mm, p < 0.001), LA volume (35.7 ± 13.2 vs. 28.9 ± 9.8 mL, p = 0.008), LV mass (118.3 ± 38.6 vs. 96.4 ± 35.4 mL, p = 0.008), CIMT (0.48 ± 0.07 vs. 0.44 ± 0.05 mm, p = 0.019), and local pulse wave velocity (LPWV; 3.7 ± 0.5 vs. 3.2 ± 0.4 m/seg, p = 0.007) were significantly increased in obese children and adolescents compared with controls. Epicardial fat showed a significant and positive correlation with LA volume, LV mass, and LPWV as well as a significant and independent association with increased CIMT (odds ratio (OR) = 3.19 [1.88-7.99], p = 0.005) in the study population. Epicardial fat thickness is linked to obesity, carotid subclinical atherosclerosis, and cardiac geometry parameters and might be a useful tool for the cardiovascular risk stratification in children and adolescents.

Original languageEnglish
Pages (from-to)450-456
Number of pages7
JournalPediatric Cardiology
Volume35
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Carotid Intima-Media Thickness
Vascular Stiffness
Fats
Pulse Wave Analysis
Carotid Artery Diseases
Carotid Arteries
Echocardiography
Case-Control Studies
Obesity
Odds Ratio
Population

Keywords

  • Atherosclerosis
  • Epicardial fat
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Cabrera-Rego, J. O., Iacobellis, G., Castillo-Herrera, J. A., Valiente-Mustelier, J., Gandarilla-Sarmientos, J. C., Marín-Juliá, S. M., & Navarrete-Cabrera, J. (2014). Epicardial fat thickness correlates with carotid intima-media thickness, arterial stiffness, and cardiac geometry in children and adolescents. Pediatric Cardiology, 35(3), 450-456. https://doi.org/10.1007/s00246-013-0799-9

Epicardial fat thickness correlates with carotid intima-media thickness, arterial stiffness, and cardiac geometry in children and adolescents. / Cabrera-Rego, Julio Oscar; Iacobellis, Gianluca; Castillo-Herrera, José Arcides; Valiente-Mustelier, Juan; Gandarilla-Sarmientos, Julio C.; Marín-Juliá, Silvia María; Navarrete-Cabrera, Juliette.

In: Pediatric Cardiology, Vol. 35, No. 3, 01.01.2014, p. 450-456.

Research output: Contribution to journalArticle

Cabrera-Rego, JO, Iacobellis, G, Castillo-Herrera, JA, Valiente-Mustelier, J, Gandarilla-Sarmientos, JC, Marín-Juliá, SM & Navarrete-Cabrera, J 2014, 'Epicardial fat thickness correlates with carotid intima-media thickness, arterial stiffness, and cardiac geometry in children and adolescents', Pediatric Cardiology, vol. 35, no. 3, pp. 450-456. https://doi.org/10.1007/s00246-013-0799-9
Cabrera-Rego, Julio Oscar ; Iacobellis, Gianluca ; Castillo-Herrera, José Arcides ; Valiente-Mustelier, Juan ; Gandarilla-Sarmientos, Julio C. ; Marín-Juliá, Silvia María ; Navarrete-Cabrera, Juliette. / Epicardial fat thickness correlates with carotid intima-media thickness, arterial stiffness, and cardiac geometry in children and adolescents. In: Pediatric Cardiology. 2014 ; Vol. 35, No. 3. pp. 450-456.
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abstract = "To determine the association between epicardial fat thickness and carotid arterial stiffness, carotid intima-media thickness (CMIT), left atrial (LA) volume, and left-ventricular (LV) geometry parameters in obese children and adolescents compared with controls. A case-control study was performed in 96 children and adolescents (obese n = 66, controls n = 30) age 9-16 years old (38 female and 58 male, mean age 11.7 ± 2.8 years) undergoing transthoracic echocardiography and carotid artery ultrasound. Clinical, anthropometric, and biochemical determinations were also recorded. Epicardial fat thickness (2.76 ± 1.2 vs. 1.36 ± 0.7 mm, p < 0.001), LA volume (35.7 ± 13.2 vs. 28.9 ± 9.8 mL, p = 0.008), LV mass (118.3 ± 38.6 vs. 96.4 ± 35.4 mL, p = 0.008), CIMT (0.48 ± 0.07 vs. 0.44 ± 0.05 mm, p = 0.019), and local pulse wave velocity (LPWV; 3.7 ± 0.5 vs. 3.2 ± 0.4 m/seg, p = 0.007) were significantly increased in obese children and adolescents compared with controls. Epicardial fat showed a significant and positive correlation with LA volume, LV mass, and LPWV as well as a significant and independent association with increased CIMT (odds ratio (OR) = 3.19 [1.88-7.99], p = 0.005) in the study population. Epicardial fat thickness is linked to obesity, carotid subclinical atherosclerosis, and cardiac geometry parameters and might be a useful tool for the cardiovascular risk stratification in children and adolescents.",
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