Epicardial Fat Thickness and Primary Aldosteronism

Gianluca Iacobellis, L. Petramala, C. Marinelli, C. Calvieri, L. Zinnamosca, A. Concistrè, G. Iannucci, G. de Toma, C. Letizia

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9 Scopus citations

Abstract

Primary aldosteronism (PA) is associated with increased cardiovascular risk and left ventricle (LV) changes. Given its peculiar biomolecular and anatomic properties, excessive epicardial fat, the heart-specific visceral fat depot, can affect LV morphology. Whether epicardial fat can be associated with aldosterone and LV mass (LVM) in patients with PA is unknown. We performed ultrasound measurement of the epicardial fat thickness (EAT) in 79 consecutive newly diagnosed patients with PA, 59 affected by bilateral adrenal hyperplasia (IHA), 20 aldosterone-producing adenoma (APA), and 30 patients with essential hypertension (low renin hypertension) (EH). The 3 groups did not differ by age, sex distribution, body mass index (BMI), waist circumference (WC), or blood pressure values. EAT showed a trend of increase in both APA and IHA groups when compared to patients with EH (8.3±1.8 vs. 7.9±1.3 vs. 7.8±2 mm, respectively). EAT was significantly correlated with indexed LVM in the IHA group (r=0.35, p

Original languageEnglish (US)
JournalHormone and Metabolic Research
DOIs
StateAccepted/In press - Aug 4 2015

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Keywords

  • epicardial fat
  • obesity
  • primary aldosteronism

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Iacobellis, G., Petramala, L., Marinelli, C., Calvieri, C., Zinnamosca, L., Concistrè, A., Iannucci, G., de Toma, G., & Letizia, C. (Accepted/In press). Epicardial Fat Thickness and Primary Aldosteronism. Hormone and Metabolic Research. https://doi.org/10.1055/s-0035-1559769