Espesor del tejido adiposo epicárdico y riesgo de diabetes tipo 2 de acuerdo al FINDRISC modificado para Latinoamérica

Translated title of the contribution: Epicardial adipose tissue thickness and type 2 diabetes risk according to the FINDRISC modified for Latin America

Marcos M. Lima-Martínez, Leomar Colmenares, Yanei Campanelli, Mariela Paoli, Marianela Rodney, Raul D. Santos, Gianluca Iacobellis

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: The Finnish Diabetes Risk Score (FINDRISC) is a tool to predict 10-year risk of type 2 diabetes mellitus (T2DM), and visceral adiposity is associated with higher cardio-metabolic risk. The objective of the study was to assess the relationship of epicardial adipose tissue (EAT) thickness with T2DM risk according to the FINDRISC tool. Methods: The study was conducted in Ciudad Bolívar, Venezuela, and included 55 subjects of whom 37 (67.3%) were women and 18 (32.7%) men with ages between 18 and 75 years. A record was made of weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, baseline insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and EAT thickness. The FINDRISC tool, with WC cut-off points modified for Latin America (LA-FINDRISC) was used. Results: BMI, WC, plasma insulin concentration, HOMA-IR index, and EAT thickness were higher (P < 0.0001) in the high-risk group compared to subjects in the low-moderate risk group according to the LA-FINDRISC. LA-FINDRISC was positively correlated with BMI (r = 0.513; P = 0.0001), WC (r = 0.524; P = 0.0001), fasting blood glucose (r = 0.396; P = 0.003); baseline plasma insulin (r = 0.483; P = 0.0001); HOMA-IR index (r = 0.545; P =.0.0001); and EAT thickness (r = 0.702; P = 0.0001). The multivariate regression analysis showed that fasting blood glucose (P = 0.023) and EAT thickness (P = 0.007) remained independently associated with high T2DM risk. Conclusions: LA-FINDRISC was associated with EAT thickness and insulin resistance markers. Both were independently and directly associated with high risk for diabetes in the LA-FINDRISC category.

Translated title of the contributionEpicardial adipose tissue thickness and type 2 diabetes risk according to the FINDRISC modified for Latin America
Original languageSpanish
JournalClinica e Investigacion en Arteriosclerosis
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Diabetes
  • Epicardial adipose tissue
  • Epicardial fat
  • FINDRISC

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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