Epicardial adipose tissue feeding and overfeeding the heart

Gianluca Iacobellis, Giuseppe Barbaro

Research output: Contribution to journalReview article

Abstract

Epicardial adipose tissue is a particular visceral fat depot with unique anatomic, biomolecular, and genetic features. Epicardial fat displays both physiological and pathological properties. Epicardial fat expresses genes and secretes cytokines actively involved in the thermogenesis and regulation of lipid and glucose metabolism of the adjacent myocardium. A disequilibrium between epicardial fat feeding and overfeeding the myocardium with free fatty acids leads to intramyocardial fat infiltration causing organ damage and clinical consequences. The upregulation of epicardial fat proinflammatory and lipogenic genes contributes to the fat build up in the proximal coronary arteries. Epicardial fat is a measurable and modifiable risk factor that can serve as a novel and additional tool for cardiovascular risk stratification. Pharmacologically targeting epicardial fat with drugs such as glucagon peptide-like 1 analogs or sodium glucose transport 2 inhibitors reduces the epicardial fat burden and induces beneficial cardiometabolic effects. Assessment and manipulation of epicardial fat transcriptome might open new avenues in the prevention of cardiometabolic diseases.

LanguageEnglish (US)
Pages1-6
Number of pages6
JournalNutrition
Volume59
DOIs
StatePublished - Mar 1 2019

Fingerprint

Intra-Abdominal Fat
Adipose Tissue
Fats
Myocardium
Glucose
Glucagon-Like Peptide 1
Thermogenesis
Lipid Metabolism
Transcriptome
Nonesterified Fatty Acids
Genes
Coronary Vessels
Up-Regulation
Sodium
Cytokines

Keywords

  • Epicardial adipose tissue
  • Epicardial fat
  • Myocardial metabolism
  • Visceral Fat

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Epicardial adipose tissue feeding and overfeeding the heart. / Iacobellis, Gianluca; Barbaro, Giuseppe.

In: Nutrition, Vol. 59, 01.03.2019, p. 1-6.

Research output: Contribution to journalReview article

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