Epicardial adipose tissue

Emerging physiological, pathophysiological and clinical features

Gianluca Iacobellis, Antonio C. Bianco

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Epicardial adipose tissue is an unusual visceral fat depot with anatomical and functional contiguity to the myocardium and coronary arteries. Under physiological conditions, epicardial adipose tissue displays biochemical, mechanical and thermogenic cardioprotective properties. Under pathological circumstances, epicardial fat can locally affect the heart and coronary arteries through vasocrine or paracrine secretion of proinflammatory cytokines. What influences this equilibrium remains unclear. Improved local vascularization, weight loss, and targeted pharmaceutical interventions could help to return epicardial fat to its physiological role. This review focuses on the emerging physiological and pathophysiological aspects of the epicardial fat and its numerous and innovative clinical applications. Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis.

Original languageEnglish
Pages (from-to)450-457
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2011

Fingerprint

Adipose Tissue
Fats
Coronary Vessels
Anti-Obesity Agents
Intra-Abdominal Fat
Atherosclerosis
Myocardium
Cytokines

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Epicardial adipose tissue : Emerging physiological, pathophysiological and clinical features. / Iacobellis, Gianluca; Bianco, Antonio C.

In: Trends in Endocrinology and Metabolism, Vol. 22, No. 11, 01.11.2011, p. 450-457.

Research output: Contribution to journalArticle

@article{cea2e424497f4db7a3ee61a628698943,
title = "Epicardial adipose tissue: Emerging physiological, pathophysiological and clinical features",
abstract = "Epicardial adipose tissue is an unusual visceral fat depot with anatomical and functional contiguity to the myocardium and coronary arteries. Under physiological conditions, epicardial adipose tissue displays biochemical, mechanical and thermogenic cardioprotective properties. Under pathological circumstances, epicardial fat can locally affect the heart and coronary arteries through vasocrine or paracrine secretion of proinflammatory cytokines. What influences this equilibrium remains unclear. Improved local vascularization, weight loss, and targeted pharmaceutical interventions could help to return epicardial fat to its physiological role. This review focuses on the emerging physiological and pathophysiological aspects of the epicardial fat and its numerous and innovative clinical applications. Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis.",
author = "Gianluca Iacobellis and Bianco, {Antonio C.}",
year = "2011",
month = "11",
day = "1",
doi = "10.1016/j.tem.2011.07.003",
language = "English",
volume = "22",
pages = "450--457",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - Epicardial adipose tissue

T2 - Emerging physiological, pathophysiological and clinical features

AU - Iacobellis, Gianluca

AU - Bianco, Antonio C.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Epicardial adipose tissue is an unusual visceral fat depot with anatomical and functional contiguity to the myocardium and coronary arteries. Under physiological conditions, epicardial adipose tissue displays biochemical, mechanical and thermogenic cardioprotective properties. Under pathological circumstances, epicardial fat can locally affect the heart and coronary arteries through vasocrine or paracrine secretion of proinflammatory cytokines. What influences this equilibrium remains unclear. Improved local vascularization, weight loss, and targeted pharmaceutical interventions could help to return epicardial fat to its physiological role. This review focuses on the emerging physiological and pathophysiological aspects of the epicardial fat and its numerous and innovative clinical applications. Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis.

AB - Epicardial adipose tissue is an unusual visceral fat depot with anatomical and functional contiguity to the myocardium and coronary arteries. Under physiological conditions, epicardial adipose tissue displays biochemical, mechanical and thermogenic cardioprotective properties. Under pathological circumstances, epicardial fat can locally affect the heart and coronary arteries through vasocrine or paracrine secretion of proinflammatory cytokines. What influences this equilibrium remains unclear. Improved local vascularization, weight loss, and targeted pharmaceutical interventions could help to return epicardial fat to its physiological role. This review focuses on the emerging physiological and pathophysiological aspects of the epicardial fat and its numerous and innovative clinical applications. Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=82455199186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455199186&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2011.07.003

DO - 10.1016/j.tem.2011.07.003

M3 - Article

VL - 22

SP - 450

EP - 457

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 11

ER -