Epicardial Adipose Tissue: Clinical Biomarker of Cardio-Metabolic Risk

Alexandra C. Villasante Fricke, Gianluca Iacobellis

Research output: Contribution to journalReview article

Abstract

Epicardial adipose tissue (EAT) is part of the visceral adipose tissue (VAT) that surrounds the heart and it is a quantifiable, modifiable, and multifaceted tissue that has both local and systemic effects. When EAT is enlarged, EAT contributes to atherosclerotic cardiovascular disease (ASCVD) risk and plays a role in the development of metabolic syndrome (MetS). In this review, we will discuss the role of EAT in various facets of MetS, including type 2 diabetes mellitus (T2DM) and insulin resistance. We examine the association between EAT and liver steatosis. We also address the correlations of EAT with HIV therapy and with psoriasis. We discuss racial differences in baseline EAT thickness. We conclude that EAT measurement serves as a powerful potential diagnostic tool in assessing cardiovascular and metabolic risk. Measurement of EAT is made less costly, more convenient, and yet accurate and reliable by transthoracic echocardiography. Furthermore, modification of EAT thickness has therapeutic implications for ASCVD, T2DM, and MetS.

Original languageEnglish (US)
JournalInternational journal of molecular sciences
Volume20
Issue number23
DOIs
StatePublished - Nov 28 2019

Fingerprint

adipose tissues
biomarkers
Biomarkers
Adipose Tissue
Tissue
diabetes mellitus
Type 2 Diabetes Mellitus
Medical problems
Cardiovascular Diseases
echocardiography
Intra-Abdominal Fat
insulin
human immunodeficiency virus
Echocardiography
Fatty Liver
Psoriasis
Insulin
liver
Insulin Resistance
Liver

Keywords

  • atherosclerotic cardiovascular risk
  • cardiometabolic risk
  • epicardial adipose tissue
  • epicardial fat
  • HIV
  • metabolic syndrome
  • psoriasis
  • race
  • visceral adipose tissue

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Epicardial Adipose Tissue : Clinical Biomarker of Cardio-Metabolic Risk. / Villasante Fricke, Alexandra C.; Iacobellis, Gianluca.

In: International journal of molecular sciences, Vol. 20, No. 23, 28.11.2019.

Research output: Contribution to journalReview article

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