Tejido adiposo epicardico y su asociacion con niveles plasmaticosde adrenomedulina en pacientes con sindrome metabolico

Translated title of the contribution: Epicardial adipose tissue and its association to plasma adrenomedullin levels inpatients with metabolic syndrome

Christopher Torres, Marcos M. Lima-Martínez, Francisco J. Rosa, Ernesto Guerra, Mariela Paoli, Gianluca Iacobellis, Marianela Rodney, Eduardo Romero-Vecchione, Maria Luisa Saadtjian, Moisés Zagala, Henry Rodney

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To assess the association between epicardial adipose tissue thickness (EAT) and plasma adrenomedullin plasma levels in patients with metabolic syndrome (MS). Methods: Twenty-one patients (12 females and 9 males) with MS according to the International Diabetes Federation guidelines, aged 22-58 years, were enrolled into the study and compared to 19 age-matched control subjects without MS. Plasma glucose, lipid, and adrenomedullin levels were assessed. EAT, left ventricular mass, and carotid intima-media thickness were evaluated by transthoracic two-dimensional echocardiography. Results: No statistically significant differences were found between the groups in age, sex, and height. Body weight, abdominal circumference (AC), body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were significantly higher (p=0.0001) in MS patients; this group also showed significantly higher glucose (p=0.001), total cholesterol (p=0.01), LDL-C (p=0.03), VLDL-C (p=0.005), triglyceride (p=0.002), Tg/HDL ratio (p=0.0001), and plasma adrenomedullin (3.49±1.21 vs 1.69±0.92 ng/mL; p=0.0001) levels and lower HDL-C (p=0.02) levels as compared to the control group. EAT was significantly thicker in MS patients compared to the control group (8.45±3.14 vs 5.43±0.96; p=0.0001), showed a positive correlation to BMI (r=0.347; p=0.02), AC (r=0.350; p=0.02), DBP (r=0.346; p=0.02), and adrenomedullin levels (r=0.741; p=0.0001). In multiple linear regression analysis, adrenomedullin was the only parameter associated to EAT (R2=0.550; p=0.0001). Conclusion: In this small patient group, a statistically significant association was found between EAT and plasma adrenomedullin levels, which may be considered as a potential biomarker of MS.

Translated title of the contributionEpicardial adipose tissue and its association to plasma adrenomedullin levels inpatients with metabolic syndrome
Original languageSpanish
Pages (from-to)401-408
Number of pages8
JournalEndocrinologia y Nutricion
Volume58
Issue number8
DOIs
StatePublished - Oct 2011

Keywords

  • Adrenomedullin
  • Atherosclerosis
  • Epicardial adipose tissue
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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  • Cite this

    Torres, C., Lima-Martínez, M. M., Rosa, F. J., Guerra, E., Paoli, M., Iacobellis, G., Rodney, M., Romero-Vecchione, E., Luisa Saadtjian, M., Zagala, M., & Rodney, H. (2011). Tejido adiposo epicardico y su asociacion con niveles plasmaticosde adrenomedulina en pacientes con sindrome metabolico. Endocrinologia y Nutricion, 58(8), 401-408. https://doi.org/10.1016/j.endonu.2011.06.002