Ephrins and Eph receptor tyrosine kinases in synapse formation

Catherine E. Krull, Daniel J. Liebl

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Here, we discuss what is known about the function of ephrins and Eph receptors in synapse formation in the peripheral nervous system and central nervous system. Ephrins have been shown to be present and functional at synapses at the neuromuscular junction and in the brain; evidence at the neuromuscular junction implicates ephrins in the topographic mapping of synapses on certain muscles. Also, certain Eph receptors also function in synapse formation but less information is known about them including their distribution and function. In addition, future directions are defined. Together, these data implicate ephrins, as well as Ephs, strongly in synaptic development.

Original languageEnglish (US)
Title of host publicationThe Sticky Synapse
Subtitle of host publicationCell Adhesion Molecules and Their Role in Synapse Formation and Maintenance
PublisherSpringer New York
Pages333-345
Number of pages13
ISBN (Electronic)9780387927084
ISBN (Print)9780387927077
DOIs
StatePublished - Jan 1 2009

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Keywords

  • CNS
  • Eph family
  • PNS
  • Synaptogenesis

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Krull, C. E., & Liebl, D. J. (2009). Ephrins and Eph receptor tyrosine kinases in synapse formation. In The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance (pp. 333-345). Springer New York. https://doi.org/10.1007/978-0-387-92708-4_16