EphrinB3 regulates cell proliferation and survival in adult neurogenesis

Jerome Ricard, Jessica Salinas, Lissette Garcia, Daniel J. Liebl

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Interactions between ephrins and their receptors have been implicated in many processes during central nervous system development. In the adult, ephrins and Eph receptors have been implicated in controlling cell proliferation and neuroblast migration, although there is no direct evidence for the role of ephrinB3 in these functions. In addition, activation of Eph receptors has been shown to regulate transduction pathways important in cell cycle control as well as cell death. We show that ephrinB3 contributes to the control of cell proliferation and survival in the adult subventricular zone (SVZ). EphrinB3 -/- mice exhibit a significant increase in dividing cells along the lateral ventricle, and altered expression of proteins involved in cell cycle regulation. Gain-of-function approach by infusing soluble ephrinB3-Fc molecules in ephrinB3-/- can suppress cell proliferation to wild type levels. At the same time, ephrinB3 also regulates cell survival as greater numbers of cells die in the SVZ of ephrinB3-/- mice. Together, our results suggest that ephrinB3 negatively regulates cell cycle progression and cell apoptosis in the adult subventricular zone.

Original languageEnglish (US)
Pages (from-to)713-722
Number of pages10
JournalMolecular and Cellular Neuroscience
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2006

Keywords

  • Apoptosis
  • Eph receptors
  • Ephrin B3
  • Proliferation
  • Stem cells
  • Subventricular zone

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

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