Eosinophilic sclerosing cholangitis associated with hypereosinophilic syndrome

L. Grauer, V. M. Padilla, L. Bouza, J. S. Barkin

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


We describe the case of a 41-yr-old man who presented with signs and symptoms of cholestasis including abdominal pain, jaundice, and fever, with peripheral eosinophilia of 10% and bone marrow eosinophilia. Liver biopsy revealed an eosinophilic infiltrate and an ERCP demonstrated bile duct changes, compatible with primary sclerosing cholangitis (PSC). After treatment with prednisone and ursodeoxycholic acid, the patient's liver profile tests returned to normal, the ERCP changes resolved, and all symptoms disappeared. A literature review has not shown any previous reports of reversible sclerosing cholangitis, secondary to eosinophilic infiltration. The purpose of this report is to describe eosinophilic cholangitis, an entity that mimics PSC in the context of the hypereosinophilic syndrome.

Original languageEnglish (US)
Pages (from-to)1764-1769
Number of pages6
JournalAmerican Journal of Gastroenterology
Issue number10
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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