Abstract
Eosinophilic cholangiopathy is a rare cholestatic disorder of unknown etiology. Simultaneous histologic documentation of eosinophilic involvement of the bile ducts and gastrointestinal tract has been reported previously in only a few well-documented cases. We report a 52-year-old man with a history of idiopathic hypereosinophilic syndrome who presented with acute diarrhea and cholestatic hepatitis. Colonoscopy revealed colitis, and a biopsy showed eosinophilic infiltrates in the colonic mucosa. Liver biopsy showed dense eosinophilic inflammation in the portal areas with bile duct damage. This case demonstrates the entity of hepatic involvement in idiopathic hypereosinophilic syndrome and the difficulties related to diagnosis and treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 574-577 |
| Number of pages | 4 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2008 |
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Keywords
- Biliary tract diseases
- Eosinophils
- Hypereosinophilic syndrome
ASJC Scopus subject areas
- Gastroenterology
Cite this
Eosinophilic cholangiopathy with concurrent eosinophilic colitis in a patient with idiopathic hypereosinophilic syndrome. / Sussman, Daniel A; Bejarano, Pablo A.; Regev, Arie.
In: European Journal of Gastroenterology and Hepatology, Vol. 20, No. 6, 01.06.2008, p. 574-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Eosinophilic cholangiopathy with concurrent eosinophilic colitis in a patient with idiopathic hypereosinophilic syndrome
AU - Sussman, Daniel A
AU - Bejarano, Pablo A.
AU - Regev, Arie
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Eosinophilic cholangiopathy is a rare cholestatic disorder of unknown etiology. Simultaneous histologic documentation of eosinophilic involvement of the bile ducts and gastrointestinal tract has been reported previously in only a few well-documented cases. We report a 52-year-old man with a history of idiopathic hypereosinophilic syndrome who presented with acute diarrhea and cholestatic hepatitis. Colonoscopy revealed colitis, and a biopsy showed eosinophilic infiltrates in the colonic mucosa. Liver biopsy showed dense eosinophilic inflammation in the portal areas with bile duct damage. This case demonstrates the entity of hepatic involvement in idiopathic hypereosinophilic syndrome and the difficulties related to diagnosis and treatment.
AB - Eosinophilic cholangiopathy is a rare cholestatic disorder of unknown etiology. Simultaneous histologic documentation of eosinophilic involvement of the bile ducts and gastrointestinal tract has been reported previously in only a few well-documented cases. We report a 52-year-old man with a history of idiopathic hypereosinophilic syndrome who presented with acute diarrhea and cholestatic hepatitis. Colonoscopy revealed colitis, and a biopsy showed eosinophilic infiltrates in the colonic mucosa. Liver biopsy showed dense eosinophilic inflammation in the portal areas with bile duct damage. This case demonstrates the entity of hepatic involvement in idiopathic hypereosinophilic syndrome and the difficulties related to diagnosis and treatment.
KW - Biliary tract diseases
KW - Eosinophils
KW - Hypereosinophilic syndrome
UR - http://www.scopus.com/inward/record.url?scp=43449132995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43449132995&partnerID=8YFLogxK
U2 - 10.1097/MEG.0b013e3282f1cc11
DO - 10.1097/MEG.0b013e3282f1cc11
M3 - Article
C2 - 18467919
AN - SCOPUS:43449132995
VL - 20
SP - 574
EP - 577
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 6
ER -