Eosinophilic cholangiopathy with concurrent eosinophilic colitis in a patient with idiopathic hypereosinophilic syndrome

Daniel A. Sussman, Pablo A Bejarano, Arie Regev

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Eosinophilic cholangiopathy is a rare cholestatic disorder of unknown etiology. Simultaneous histologic documentation of eosinophilic involvement of the bile ducts and gastrointestinal tract has been reported previously in only a few well-documented cases. We report a 52-year-old man with a history of idiopathic hypereosinophilic syndrome who presented with acute diarrhea and cholestatic hepatitis. Colonoscopy revealed colitis, and a biopsy showed eosinophilic infiltrates in the colonic mucosa. Liver biopsy showed dense eosinophilic inflammation in the portal areas with bile duct damage. This case demonstrates the entity of hepatic involvement in idiopathic hypereosinophilic syndrome and the difficulties related to diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)574-577
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2008

Keywords

  • Biliary tract diseases
  • Eosinophils
  • Hypereosinophilic syndrome

ASJC Scopus subject areas

  • Gastroenterology

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