1. 1. The activity of the key enzymes involved in the synthesis and degradation of glycogen in the avian glycogen body was investigated in this study. The glycogen body was found to harbor activities of "debrancher", total phosphorylase, "brancher", phosphorylase-b-kinase, "glycogen synthetase", phosphohexose isomerase, phosphoglucomutase, α-1,4-glucosidase, pyruvate kinase, phosphofructokinase, fructose-1,6-diphosphate aldolase and fructose-1-phosphate aldolase within the range of that normally seen in mammalian liver samples. 2. 2. Glucose-6-phosphatase activity was absent, even in the presence of trehalose, a known stimulator of glucose-6-phosphate hydrolysis. The absence of glucose-6-phosphatase activity indicates that the glycogen body cannot provide glucose for the central nervous system. 3. 3. The glycogen body may serve as a model for the study of Type I glycogen storage disease.
|Original language||English (US)|
|Journal||Comparative Biochemistry and Physiology -- Part B: Biochemistry and|
|State||Published - Apr 15 1975|
- Avian glycogen body
- glycogen enzymes
- glycogen synthesis and degradation
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