Enzymatic and biochemical characterization of the avian glycogen body

Aaron S. Fink, Patrick M. Hefferan, R. Rodney Howell

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

1. 1. The activity of the key enzymes involved in the synthesis and degradation of glycogen in the avian glycogen body was investigated in this study. The glycogen body was found to harbor activities of "debrancher", total phosphorylase, "brancher", phosphorylase-b-kinase, "glycogen synthetase", phosphohexose isomerase, phosphoglucomutase, α-1,4-glucosidase, pyruvate kinase, phosphofructokinase, fructose-1,6-diphosphate aldolase and fructose-1-phosphate aldolase within the range of that normally seen in mammalian liver samples. 2. 2. Glucose-6-phosphatase activity was absent, even in the presence of trehalose, a known stimulator of glucose-6-phosphate hydrolysis. The absence of glucose-6-phosphatase activity indicates that the glycogen body cannot provide glucose for the central nervous system. 3. 3. The glycogen body may serve as a model for the study of Type I glycogen storage disease.

Original languageEnglish (US)
Pages (from-to)525-528,IN1-IN2,529-530
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume50
Issue number4
DOIs
StatePublished - Apr 15 1975
Externally publishedYes

Keywords

  • Avian glycogen body
  • glucose-6-phosphatase
  • glycogen enzymes
  • glycogen synthesis and degradation

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Enzymatic and biochemical characterization of the avian glycogen body'. Together they form a unique fingerprint.

  • Cite this