TY - JOUR
T1 - Enthesopathy-An Underappreciated Role in Osteoarthritis?
AU - Greif, Dylan N.
AU - Emerson, Christopher P.
AU - Jose, Jean
AU - Toumi, Hechmi
AU - Best, Thomas M.
N1 - Publisher Copyright:
© Lippincott Williams and Wilkins.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Osteoarthritis (OA) continues to be a debilitating disease worldwide, to date, no therapies have been definitely proven to modify disease progression or moderate symptom relief long term other than joint replacement. A contributing factor may be the lack of attention to the potential role of the periarticular enthesis and development and progression of OA. The enthesis is the site of attachment for a tendon, ligament, or joint capsule to the bony skeleton, thereby allowing centralized transmission and dissipation of mechanical loads. Because of this design, the enthesis is a site of stress concentration subject to inflammation during sports-related activities or spondyloarthropathies, which may lead to long-term degeneration. Our hypothesis is that functional incompetence of the enthesis resulting from either degenerative or inflammatory changes could be an initiating factor for OA and may thus provide a novel basis for the development of future disease management in this phenotype of patients.
AB - Osteoarthritis (OA) continues to be a debilitating disease worldwide, to date, no therapies have been definitely proven to modify disease progression or moderate symptom relief long term other than joint replacement. A contributing factor may be the lack of attention to the potential role of the periarticular enthesis and development and progression of OA. The enthesis is the site of attachment for a tendon, ligament, or joint capsule to the bony skeleton, thereby allowing centralized transmission and dissipation of mechanical loads. Because of this design, the enthesis is a site of stress concentration subject to inflammation during sports-related activities or spondyloarthropathies, which may lead to long-term degeneration. Our hypothesis is that functional incompetence of the enthesis resulting from either degenerative or inflammatory changes could be an initiating factor for OA and may thus provide a novel basis for the development of future disease management in this phenotype of patients.
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U2 - 10.1249/JSR.0000000000000775
DO - 10.1249/JSR.0000000000000775
M3 - Article
C2 - 33156036
AN - SCOPUS:85095861869
VL - 19
SP - 495
EP - 497
JO - Current Sports Medicine Reports
JF - Current Sports Medicine Reports
SN - 1537-890X
IS - 11
ER -