Enterotoxigenic Escherichia coli: Orchestrated host engagement

James M. Fleckenstein, George M. Munson, David A. Rasko

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The enterotoxigenic Escherichia coli are a pervasive cause of serious diarrheal illness in developing countries. Presently, there is no vaccine to prevent these infections, and many features of the basic pathogenesis of these organisms remain poorly understood. Until very recently most pathogenesis studies had focused almost exclusively on a small subset of known "classical" virulence genes, namely fimbrial colonization factors and the heat-labile (LT) and heat stable (ST) enterotoxins. However, recent investigations of pathogen-host interactions reveal a surprisingly complex and intricately orchestrated engagement involving the interplay of classical, and "novel" virulence genes, as well as participation of genes highly conserved in the E. coli species. These studies may inform further rational approaches to vaccine development for these important pathogens.

Original languageEnglish (US)
JournalGut Microbes
Volume4
Issue number5
DOIs
StatePublished - Jan 1 2013

Keywords

  • Adhesins
  • Bacterial
  • Enterotoxigenic Escherichia coli
  • Escherichia coli vaccines
  • Gene expression profiling
  • Host-pathogen interaction
  • Transcriptome

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

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