Enteropathy-associated T-cell lymphoma and its immunocarcinogenic correlates: Case report and review of the literature

Ana Palacio, Leonardo Tamariz, Jonathan Berger, Roberto Patarca

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

We report a case of enteropathy-associated T-cell lymphoma (EATL), diagnosed by small intestine and gastric biopsies, who presented with manifestations of hypocalcemia and malabsorption. Immunonological assessment revealed increased expression levels of tumor necrosis factor system components and eotaxin, an observation that is consistent with the cytotoxic T-cell phenotype characteristic of EATL, and decreased numbers of circulating activated (CD8+CD38+ and CD4+CD25+) and suppressor (CD11b+) T cells, a feature which can contribute to lymphomagenesis in patients with celiac disease. The acute clinical presentation of the patient resolved with mineral and vitamin supplementation and a gluten-free diet. The novel immunological findings described are discussed in the context of a review of our current knowledge of the immunopathogenesis of celiac disease and associated intestinal neoplasia.

Original languageEnglish (US)
Pages (from-to)63-81
Number of pages19
JournalCritical reviews in oncogenesis
Volume9
Issue number1
StatePublished - Oct 5 1998

Keywords

  • Celiac disease
  • Cytokines
  • Endomysium
  • Eotaxin
  • Gliadin
  • Gluten
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Cancer Research

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