Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis

Martin R. Turner, Michael Benatar

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Multiple candidate biomarkers for amyotrophic lateral sclerosis (ALS) have emerged across a range of platforms. Replication of results, however, has been absent in all but a few cases, and the range of control samples has been limited. If progress toward clinical translation is to continue, the specific biomarker needs of ALS, which differ from those of other neurodegenerative disorders, as well as the challenges inherent to longitudinal ALS biomarker cohorts, must be understood. Appropriate application of multimodal approaches, international collaboration, presymptomatic studies, and biomarker integration into future therapeutic trials are among the essential priorities going forward.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalMuscle and Nerve
Issue number1
StatePublished - Jan 1 2015


  • Biomarker
  • Motor neuron disease
  • Neurochemistry
  • Neuroimaging
  • Trial

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology


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