Enkephalin inhibits the release and action of secretin on pancreatic secretion

S. J. Konturek, J. Tasler, A. V. Schally, W. Y. Chey

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Abstract

Methionine-enkephalin (Met-Enk) inhibits pancreatic secretion stimulated by exogenous secretin and cholecystokinin (Gastroenterology 74:851, 1978). In the present study, the influence of Met-Enk on release and action of secretin on exocrine pancreas was investigated in 3 dogs. These studies indicate that Met-Enk causes more pronounced inhibition of exocrine pancreatic response to endogenous stimulants such as food and duodenal acidification than to exogenous secretin and that this inhibitory affect is accompanied by a significant suppression of PS. We conclude that Met-Enk inhibits pancreatic secretion at least in part by suppression of secretin release and that this inhibitory action may be mediated by a special opiate receptor.

Original languageEnglish (US)
Number of pages1
JournalGastroenterology
Volume76
Issue number5 II
StatePublished - Jan 1 1979

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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