Enkephalin inhibits the release and action of secretin on pancreatic secretion

S. J. Konturek; J. Tasler; A. V. Schally; W. Y. Chey

Enkephalin inhibits the release and action of secretin on pancreatic secretion

S. J. Konturek, J. Tasler, A. V. Schally, W. Y. Chey

Research output: Contribution to journal › Article › peer-review

Abstract

Methionine-enkephalin (Met-Enk) inhibits pancreatic secretion stimulated by exogenous secretin and cholecystokinin (Gastroenterology 74:851, 1978). In the present study, the influence of Met-Enk on release and action of secretin on exocrine pancreas was investigated in 3 dogs. These studies indicate that Met-Enk causes more pronounced inhibition of exocrine pancreatic response to endogenous stimulants such as food and duodenal acidification than to exogenous secretin and that this inhibitory affect is accompanied by a significant suppression of PS. We conclude that Met-Enk inhibits pancreatic secretion at least in part by suppression of secretin release and that this inhibitory action may be mediated by a special opiate receptor.

Original language	English (US)
Number of pages	1
Journal	Gastroenterology
Volume	76
Issue number	5 II
State	Published - Jan 1 1979
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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title = "Enkephalin inhibits the release and action of secretin on pancreatic secretion",

abstract = "Methionine-enkephalin (Met-Enk) inhibits pancreatic secretion stimulated by exogenous secretin and cholecystokinin (Gastroenterology 74:851, 1978). In the present study, the influence of Met-Enk on release and action of secretin on exocrine pancreas was investigated in 3 dogs. These studies indicate that Met-Enk causes more pronounced inhibition of exocrine pancreatic response to endogenous stimulants such as food and duodenal acidification than to exogenous secretin and that this inhibitory affect is accompanied by a significant suppression of PS. We conclude that Met-Enk inhibits pancreatic secretion at least in part by suppression of secretin release and that this inhibitory action may be mediated by a special opiate receptor.",

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T1 - Enkephalin inhibits the release and action of secretin on pancreatic secretion

AU - Konturek, S. J.

AU - Tasler, J.

AU - Schally, A. V.

AU - Chey, W. Y.

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N2 - Methionine-enkephalin (Met-Enk) inhibits pancreatic secretion stimulated by exogenous secretin and cholecystokinin (Gastroenterology 74:851, 1978). In the present study, the influence of Met-Enk on release and action of secretin on exocrine pancreas was investigated in 3 dogs. These studies indicate that Met-Enk causes more pronounced inhibition of exocrine pancreatic response to endogenous stimulants such as food and duodenal acidification than to exogenous secretin and that this inhibitory affect is accompanied by a significant suppression of PS. We conclude that Met-Enk inhibits pancreatic secretion at least in part by suppression of secretin release and that this inhibitory action may be mediated by a special opiate receptor.

AB - Methionine-enkephalin (Met-Enk) inhibits pancreatic secretion stimulated by exogenous secretin and cholecystokinin (Gastroenterology 74:851, 1978). In the present study, the influence of Met-Enk on release and action of secretin on exocrine pancreas was investigated in 3 dogs. These studies indicate that Met-Enk causes more pronounced inhibition of exocrine pancreatic response to endogenous stimulants such as food and duodenal acidification than to exogenous secretin and that this inhibitory affect is accompanied by a significant suppression of PS. We conclude that Met-Enk inhibits pancreatic secretion at least in part by suppression of secretin release and that this inhibitory action may be mediated by a special opiate receptor.

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