Methionine-enkephalin (Met-Enk) inhibits pancreatic secretion stimulated by exogenous secretin and cholecystokinin (Gastroenterology 74:851, 1978). In the present study, the influence of Met-Enk on release and action of secretin on exocrine pancreas was investigated in 3 dogs. These studies indicate that Met-Enk causes more pronounced inhibition of exocrine pancreatic response to endogenous stimulants such as food and duodenal acidification than to exogenous secretin and that this inhibitory affect is accompanied by a significant suppression of PS. We conclude that Met-Enk inhibits pancreatic secretion at least in part by suppression of secretin release and that this inhibitory action may be mediated by a special opiate receptor.
|Original language||English (US)|
|Number of pages||1|
|Issue number||5 II|
|State||Published - Jan 1 1979|
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