Abstract
Methionine-enkephalin (Met-Enk) inhibits pancreatic secretion stimulated by exogenous secretin and cholecystokinin (Gastroenterology 74:851, 1978). In the present study, the influence of Met-Enk on release and action of secretin on exocrine pancreas was investigated in 3 dogs. These studies indicate that Met-Enk causes more pronounced inhibition of exocrine pancreatic response to endogenous stimulants such as food and duodenal acidification than to exogenous secretin and that this inhibitory affect is accompanied by a significant suppression of PS. We conclude that Met-Enk inhibits pancreatic secretion at least in part by suppression of secretin release and that this inhibitory action may be mediated by a special opiate receptor.
| Original language | English (US) |
|---|---|
| Number of pages | 1 |
| Journal | Gastroenterology |
| Volume | 76 |
| Issue number | 5 II |
| State | Published - Jan 1 1979 |
| Externally published | Yes |
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
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Cite this
Konturek, S. J., Tasler, J., Schally, A. V., & Chey, W. Y. (1979). Enkephalin inhibits the release and action of secretin on pancreatic secretion. Gastroenterology, 76(5 II).