Enhancing recovery in coronary heart disease (ENRICHD) study intervention: Rationale and design

L. Berkman, A. Jaffe, R. Carney, S. Czajkowski, P. Kaufman, J. A. Blumenthal, P. Arias, M. Babyak, T. Baldewicz, J. Barefoot, J. Bennett, R. Carels, B. Crenshaw, S. Curtis, L. Davis, K. Fath, L. Forman, A. Hassett, S. B. Hegde, S. H. HermanA. Hinderliter, P. Khatri, W. Kraus, R. Krishnan, S. Levenberg, D. Mark, P. Marz, R. McCarthy, G. Miller, J. Norten, C. O'Connor, J. Puma, L. Rutt, W. Sessions, I. Siegler, L. Watkins, R. Waugh, R. Williams, A. Wilson, B. G. Zakhary, L. H. Powell, J. E. Calvin, D. C. Clark, S. Creech, D. Downs, C. Eaton, W. J. Elliott, L. Kassem, A. Luten, C. M. De Leon, W. S. Miles, R. Munoz-Dunbar, P. Pfenninger, C. R. Pitula, S. Szeplakay, J. Zajecka, J. Zander, R. F. Debusk, L. Balenesi, A. Casteneda, A. Deeter, S. Duenke, L. F. Forseth, E. S. Froelicher, R. Hanna, H. Kaiser, S. Lamb, S. Madan, M. Marnell, N. H. Miller, K. Parker, D. Strachowski, B. Taylor, C. E. Thoresen, J. Raczynski, B. Adams, S. Allison, M. Bandy, J. Barton, L. Bates, V. Bittner, M. Cole, C. E. Cornell, V. DiLillo, J. Dolce, J. Gilliland, S. Jordan, J. Markovitz, D. Mason, J. Shuster, P. White, S. Winders, Neil Schneiderman, Marc Gellman, Gail Ironson, K. Kilbourn, M. E. Manrique-Reichard, Judith McCalla, T. Mellman

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Objective: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social support in post-MI patients. A total of 2481 patients were recruited (26% with low social support, 39% with depression, and 34% with low social support and depression). Our objective is to describe the rationale, design, and delivery of the ENRICHD intervention. Methods: Key features of the intervention include the integration of cognitive-behavioral and social learning approaches to the treatment of depression and a diverse set of problems that can contribute to low social support; rapid initiation of treatment after MI; a combination of individual and group modalities; adjunctive pharmacotherapy for severe or intractable depression; training, certification, and supervision of therapists; and quality assurance procedures. Results: The trial's psychosocial and medical outcomes will be presented in future reports. Conclusions: The ENRICHD protocol targets two complex psychosocial risk factors with a multifaceted intervention, which is delivered in an individualized manner to accommodate a demographically, medically, and psychiatrically diverse patient population. Additional research will be needed to identify optimal matches between patient characteristics and specific components of the intervention.

Original languageEnglish
Pages (from-to)747-755
Number of pages9
JournalPsychosomatic Medicine
Volume63
Issue number5
StatePublished - Oct 10 2001
Externally publishedYes

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Coronary Disease
Social Support
Depression
Certification
Therapeutics
Randomized Controlled Trials
Psychology
Morbidity
Drug Therapy
Mortality
Research
Population

Keywords

  • Clinical trials
  • Coronary heart disease
  • Depression
  • Myocardial infarction
  • Social support

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Berkman, L., Jaffe, A., Carney, R., Czajkowski, S., Kaufman, P., Blumenthal, J. A., ... Mellman, T. (2001). Enhancing recovery in coronary heart disease (ENRICHD) study intervention: Rationale and design. Psychosomatic Medicine, 63(5), 747-755.

Enhancing recovery in coronary heart disease (ENRICHD) study intervention : Rationale and design. / Berkman, L.; Jaffe, A.; Carney, R.; Czajkowski, S.; Kaufman, P.; Blumenthal, J. A.; Arias, P.; Babyak, M.; Baldewicz, T.; Barefoot, J.; Bennett, J.; Carels, R.; Crenshaw, B.; Curtis, S.; Davis, L.; Fath, K.; Forman, L.; Hassett, A.; Hegde, S. B.; Herman, S. H.; Hinderliter, A.; Khatri, P.; Kraus, W.; Krishnan, R.; Levenberg, S.; Mark, D.; Marz, P.; McCarthy, R.; Miller, G.; Norten, J.; O'Connor, C.; Puma, J.; Rutt, L.; Sessions, W.; Siegler, I.; Watkins, L.; Waugh, R.; Williams, R.; Wilson, A.; Zakhary, B. G.; Powell, L. H.; Calvin, J. E.; Clark, D. C.; Creech, S.; Downs, D.; Eaton, C.; Elliott, W. J.; Kassem, L.; Luten, A.; De Leon, C. M.; Miles, W. S.; Munoz-Dunbar, R.; Pfenninger, P.; Pitula, C. R.; Szeplakay, S.; Zajecka, J.; Zander, J.; Debusk, R. F.; Balenesi, L.; Casteneda, A.; Deeter, A.; Duenke, S.; Forseth, L. F.; Froelicher, E. S.; Hanna, R.; Kaiser, H.; Lamb, S.; Madan, S.; Marnell, M.; Miller, N. H.; Parker, K.; Strachowski, D.; Taylor, B.; Thoresen, C. E.; Raczynski, J.; Adams, B.; Allison, S.; Bandy, M.; Barton, J.; Bates, L.; Bittner, V.; Cole, M.; Cornell, C. E.; DiLillo, V.; Dolce, J.; Gilliland, J.; Jordan, S.; Markovitz, J.; Mason, D.; Shuster, J.; White, P.; Winders, S.; Schneiderman, Neil; Gellman, Marc; Ironson, Gail; Kilbourn, K.; Manrique-Reichard, M. E.; McCalla, Judith; Mellman, T.

In: Psychosomatic Medicine, Vol. 63, No. 5, 10.10.2001, p. 747-755.

Research output: Contribution to journalArticle

Berkman, L, Jaffe, A, Carney, R, Czajkowski, S, Kaufman, P, Blumenthal, JA, Arias, P, Babyak, M, Baldewicz, T, Barefoot, J, Bennett, J, Carels, R, Crenshaw, B, Curtis, S, Davis, L, Fath, K, Forman, L, Hassett, A, Hegde, SB, Herman, SH, Hinderliter, A, Khatri, P, Kraus, W, Krishnan, R, Levenberg, S, Mark, D, Marz, P, McCarthy, R, Miller, G, Norten, J, O'Connor, C, Puma, J, Rutt, L, Sessions, W, Siegler, I, Watkins, L, Waugh, R, Williams, R, Wilson, A, Zakhary, BG, Powell, LH, Calvin, JE, Clark, DC, Creech, S, Downs, D, Eaton, C, Elliott, WJ, Kassem, L, Luten, A, De Leon, CM, Miles, WS, Munoz-Dunbar, R, Pfenninger, P, Pitula, CR, Szeplakay, S, Zajecka, J, Zander, J, Debusk, RF, Balenesi, L, Casteneda, A, Deeter, A, Duenke, S, Forseth, LF, Froelicher, ES, Hanna, R, Kaiser, H, Lamb, S, Madan, S, Marnell, M, Miller, NH, Parker, K, Strachowski, D, Taylor, B, Thoresen, CE, Raczynski, J, Adams, B, Allison, S, Bandy, M, Barton, J, Bates, L, Bittner, V, Cole, M, Cornell, CE, DiLillo, V, Dolce, J, Gilliland, J, Jordan, S, Markovitz, J, Mason, D, Shuster, J, White, P, Winders, S, Schneiderman, N, Gellman, M, Ironson, G, Kilbourn, K, Manrique-Reichard, ME, McCalla, J & Mellman, T 2001, 'Enhancing recovery in coronary heart disease (ENRICHD) study intervention: Rationale and design', Psychosomatic Medicine, vol. 63, no. 5, pp. 747-755.
Berkman L, Jaffe A, Carney R, Czajkowski S, Kaufman P, Blumenthal JA et al. Enhancing recovery in coronary heart disease (ENRICHD) study intervention: Rationale and design. Psychosomatic Medicine. 2001 Oct 10;63(5):747-755.
Berkman, L. ; Jaffe, A. ; Carney, R. ; Czajkowski, S. ; Kaufman, P. ; Blumenthal, J. A. ; Arias, P. ; Babyak, M. ; Baldewicz, T. ; Barefoot, J. ; Bennett, J. ; Carels, R. ; Crenshaw, B. ; Curtis, S. ; Davis, L. ; Fath, K. ; Forman, L. ; Hassett, A. ; Hegde, S. B. ; Herman, S. H. ; Hinderliter, A. ; Khatri, P. ; Kraus, W. ; Krishnan, R. ; Levenberg, S. ; Mark, D. ; Marz, P. ; McCarthy, R. ; Miller, G. ; Norten, J. ; O'Connor, C. ; Puma, J. ; Rutt, L. ; Sessions, W. ; Siegler, I. ; Watkins, L. ; Waugh, R. ; Williams, R. ; Wilson, A. ; Zakhary, B. G. ; Powell, L. H. ; Calvin, J. E. ; Clark, D. C. ; Creech, S. ; Downs, D. ; Eaton, C. ; Elliott, W. J. ; Kassem, L. ; Luten, A. ; De Leon, C. M. ; Miles, W. S. ; Munoz-Dunbar, R. ; Pfenninger, P. ; Pitula, C. R. ; Szeplakay, S. ; Zajecka, J. ; Zander, J. ; Debusk, R. F. ; Balenesi, L. ; Casteneda, A. ; Deeter, A. ; Duenke, S. ; Forseth, L. F. ; Froelicher, E. S. ; Hanna, R. ; Kaiser, H. ; Lamb, S. ; Madan, S. ; Marnell, M. ; Miller, N. H. ; Parker, K. ; Strachowski, D. ; Taylor, B. ; Thoresen, C. E. ; Raczynski, J. ; Adams, B. ; Allison, S. ; Bandy, M. ; Barton, J. ; Bates, L. ; Bittner, V. ; Cole, M. ; Cornell, C. E. ; DiLillo, V. ; Dolce, J. ; Gilliland, J. ; Jordan, S. ; Markovitz, J. ; Mason, D. ; Shuster, J. ; White, P. ; Winders, S. ; Schneiderman, Neil ; Gellman, Marc ; Ironson, Gail ; Kilbourn, K. ; Manrique-Reichard, M. E. ; McCalla, Judith ; Mellman, T. / Enhancing recovery in coronary heart disease (ENRICHD) study intervention : Rationale and design. In: Psychosomatic Medicine. 2001 ; Vol. 63, No. 5. pp. 747-755.
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abstract = "Objective: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social support in post-MI patients. A total of 2481 patients were recruited (26{\%} with low social support, 39{\%} with depression, and 34{\%} with low social support and depression). Our objective is to describe the rationale, design, and delivery of the ENRICHD intervention. Methods: Key features of the intervention include the integration of cognitive-behavioral and social learning approaches to the treatment of depression and a diverse set of problems that can contribute to low social support; rapid initiation of treatment after MI; a combination of individual and group modalities; adjunctive pharmacotherapy for severe or intractable depression; training, certification, and supervision of therapists; and quality assurance procedures. Results: The trial's psychosocial and medical outcomes will be presented in future reports. Conclusions: The ENRICHD protocol targets two complex psychosocial risk factors with a multifaceted intervention, which is delivered in an individualized manner to accommodate a demographically, medically, and psychiatrically diverse patient population. Additional research will be needed to identify optimal matches between patient characteristics and specific components of the intervention.",
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TY - JOUR

T1 - Enhancing recovery in coronary heart disease (ENRICHD) study intervention

T2 - Rationale and design

AU - Berkman, L.

AU - Jaffe, A.

AU - Carney, R.

AU - Czajkowski, S.

AU - Kaufman, P.

AU - Blumenthal, J. A.

AU - Arias, P.

AU - Babyak, M.

AU - Baldewicz, T.

AU - Barefoot, J.

AU - Bennett, J.

AU - Carels, R.

AU - Crenshaw, B.

AU - Curtis, S.

AU - Davis, L.

AU - Fath, K.

AU - Forman, L.

AU - Hassett, A.

AU - Hegde, S. B.

AU - Herman, S. H.

AU - Hinderliter, A.

AU - Khatri, P.

AU - Kraus, W.

AU - Krishnan, R.

AU - Levenberg, S.

AU - Mark, D.

AU - Marz, P.

AU - McCarthy, R.

AU - Miller, G.

AU - Norten, J.

AU - O'Connor, C.

AU - Puma, J.

AU - Rutt, L.

AU - Sessions, W.

AU - Siegler, I.

AU - Watkins, L.

AU - Waugh, R.

AU - Williams, R.

AU - Wilson, A.

AU - Zakhary, B. G.

AU - Powell, L. H.

AU - Calvin, J. E.

AU - Clark, D. C.

AU - Creech, S.

AU - Downs, D.

AU - Eaton, C.

AU - Elliott, W. J.

AU - Kassem, L.

AU - Luten, A.

AU - De Leon, C. M.

AU - Miles, W. S.

AU - Munoz-Dunbar, R.

AU - Pfenninger, P.

AU - Pitula, C. R.

AU - Szeplakay, S.

AU - Zajecka, J.

AU - Zander, J.

AU - Debusk, R. F.

AU - Balenesi, L.

AU - Casteneda, A.

AU - Deeter, A.

AU - Duenke, S.

AU - Forseth, L. F.

AU - Froelicher, E. S.

AU - Hanna, R.

AU - Kaiser, H.

AU - Lamb, S.

AU - Madan, S.

AU - Marnell, M.

AU - Miller, N. H.

AU - Parker, K.

AU - Strachowski, D.

AU - Taylor, B.

AU - Thoresen, C. E.

AU - Raczynski, J.

AU - Adams, B.

AU - Allison, S.

AU - Bandy, M.

AU - Barton, J.

AU - Bates, L.

AU - Bittner, V.

AU - Cole, M.

AU - Cornell, C. E.

AU - DiLillo, V.

AU - Dolce, J.

AU - Gilliland, J.

AU - Jordan, S.

AU - Markovitz, J.

AU - Mason, D.

AU - Shuster, J.

AU - White, P.

AU - Winders, S.

AU - Schneiderman, Neil

AU - Gellman, Marc

AU - Ironson, Gail

AU - Kilbourn, K.

AU - Manrique-Reichard, M. E.

AU - McCalla, Judith

AU - Mellman, T.

PY - 2001/10/10

Y1 - 2001/10/10

N2 - Objective: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social support in post-MI patients. A total of 2481 patients were recruited (26% with low social support, 39% with depression, and 34% with low social support and depression). Our objective is to describe the rationale, design, and delivery of the ENRICHD intervention. Methods: Key features of the intervention include the integration of cognitive-behavioral and social learning approaches to the treatment of depression and a diverse set of problems that can contribute to low social support; rapid initiation of treatment after MI; a combination of individual and group modalities; adjunctive pharmacotherapy for severe or intractable depression; training, certification, and supervision of therapists; and quality assurance procedures. Results: The trial's psychosocial and medical outcomes will be presented in future reports. Conclusions: The ENRICHD protocol targets two complex psychosocial risk factors with a multifaceted intervention, which is delivered in an individualized manner to accommodate a demographically, medically, and psychiatrically diverse patient population. Additional research will be needed to identify optimal matches between patient characteristics and specific components of the intervention.

AB - Objective: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social support in post-MI patients. A total of 2481 patients were recruited (26% with low social support, 39% with depression, and 34% with low social support and depression). Our objective is to describe the rationale, design, and delivery of the ENRICHD intervention. Methods: Key features of the intervention include the integration of cognitive-behavioral and social learning approaches to the treatment of depression and a diverse set of problems that can contribute to low social support; rapid initiation of treatment after MI; a combination of individual and group modalities; adjunctive pharmacotherapy for severe or intractable depression; training, certification, and supervision of therapists; and quality assurance procedures. Results: The trial's psychosocial and medical outcomes will be presented in future reports. Conclusions: The ENRICHD protocol targets two complex psychosocial risk factors with a multifaceted intervention, which is delivered in an individualized manner to accommodate a demographically, medically, and psychiatrically diverse patient population. Additional research will be needed to identify optimal matches between patient characteristics and specific components of the intervention.

KW - Clinical trials

KW - Coronary heart disease

KW - Depression

KW - Myocardial infarction

KW - Social support

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M3 - Article

C2 - 11573023

AN - SCOPUS:0034807282

VL - 63

SP - 747

EP - 755

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 5

ER -