Enhancing clinical islet transplantation through tissue engineeering strategies

Jaime A. Giraldo, Jessica D. Weaver, Cherie L. Stabler

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Clinical islet transplantation (CIT), the infusion of allogeneic islets within the liver, has the potential to provide precise and sustainable control of blood glucose levels for the treatment of type 1 diabetes. The success and long?term outcomes of CIT, however, are limited by obstacles such as a nonoptimal transplantation site and severe inflammatory and immunological responses to the transplant. Tissue engineering strategies are poised to combat these challenges. In this review, emerging methods for engineering an optimal islet transplantation site, as well as novel approaches for improving islet cell encapsulation, are discussed.

Original languageEnglish (US)
Pages (from-to)1238-1247
Number of pages10
JournalJournal of Diabetes Science and Technology
Volume4
Issue number5
DOIs
StatePublished - Sep 2010

Keywords

  • Bioartificial pancreas
  • Biomaterials
  • Devices
  • Encapsulation
  • Islet transplantation
  • Scaffold

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Bioengineering
  • Biomedical Engineering

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