Enhancer RNAs: The new molecules of transcription

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

In the past few years, technological advances in nucleotide sequencing have culminated in a greater understanding of the complexity of the human transcriptome. Notably, the discovery that distal regulatory elements known as enhancers are transcribed and such enhancer-derived transcripts (eRNAs) serve a critical function in transcriptional activation has added a new dimension to transcriptional regulation. Here we review recent insights into the tissue-specific and temporal-specific gene regulation brought about by the discovery of eRNAs.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalCurrent Opinion in Genetics and Development
Volume25
Issue number1
DOIs
StatePublished - Apr 2014

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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