Enhancement of high intensity iodine-125 brachytherapy by cis-platinum in a murine bladder tumor model

S. Nag, A. Blatnik, M. Soloway

Research output: Contribution to journalArticle

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Abstract

The interaction of cis-platinum chemotherapy and high-intensity Iodine-125 brachytherapy was studied in C3H/He mice with MBT-2 tumors growing in the thigh. Brachytherapy was delivered by 3 Iodine-125 seeds of 10 mCi each implanted into the tumor. Ninety-six animals were randomly divided into 8 groups of 12 animals each. Each group was given either no treatment (control), cisplatinum alone or brachytherapy of 20, 40 or 50 Gy either alone or combined with cis-platinum. Cis-platinum 3 mg. per kg. was given every 5 days for 3 doses. The addition of cis-platinum enhanced the effects of Iodine-125 brachytherapy as shown by the end-points of tumor regrowth delay, local tumor control and median survival times. The sensitization enhancement ratio ranged from 1.2 to 1.9. Further experiments are to be conducted to study the normal tissue effect, therapeutic gain factor, effects of altering the time of administration of cis-platinum and the clinical use of high-intensity Iodine-125 for removable brachytherapy.

Original languageEnglish
Pages (from-to)1225-1228
Number of pages4
JournalJournal of Urology
Volume131
Issue number6
StatePublished - Jan 1 1984
Externally publishedYes

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Brachytherapy
Urinary Bladder Neoplasms
Iodine
Cisplatin
Neoplasms
Inbred C3H Mouse
Therapeutic Uses
Thigh
Seeds
Drug Therapy

ASJC Scopus subject areas

  • Urology

Cite this

Enhancement of high intensity iodine-125 brachytherapy by cis-platinum in a murine bladder tumor model. / Nag, S.; Blatnik, A.; Soloway, M.

In: Journal of Urology, Vol. 131, No. 6, 01.01.1984, p. 1225-1228.

Research output: Contribution to journalArticle

Nag, S. ; Blatnik, A. ; Soloway, M. / Enhancement of high intensity iodine-125 brachytherapy by cis-platinum in a murine bladder tumor model. In: Journal of Urology. 1984 ; Vol. 131, No. 6. pp. 1225-1228.
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