Enhancement of ethanol-induced sedation and hypothermia by centrally administered neurotensin, β-endorphin and bombesin

D. Luttinger, Charles Nemeroff, G. A. Mason, G. D. Frye, G. R. Breese, A. J. Prange

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Intracisternal administration of three endogenous neuropeptides (neurotensin, β-endorphin, or bombesin) potentiated the duration of sedation induced by a fixed dose of ethanol (5.2 g/kg) in mice. The minimally effective dose of each peptide that enhanced ethanol-induced sedation was: neurotensin, 0.18 nmoles; β-endorphin, 1.79 nmoles; and bombesin, 0.06 nmoles. The enhancement of ethanol-induced sedation was correlated with the potentiation of ethanol-induced hypothermia for all three peptides. None of the neuropeptides studied significantly altered blood or brain ethanol concentrations, suggesting that the observed effects were not due to differences in ethanol metabolism.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalNeuropharmacology
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Endorphins
Induced Hypothermia
Bombesin
Neurotensin
Ethanol
Neuropeptides
Peptides
Brain

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Enhancement of ethanol-induced sedation and hypothermia by centrally administered neurotensin, β-endorphin and bombesin. / Luttinger, D.; Nemeroff, Charles; Mason, G. A.; Frye, G. D.; Breese, G. R.; Prange, A. J.

In: Neuropharmacology, Vol. 20, No. 3, 01.01.1981, p. 305-309.

Research output: Contribution to journalArticle

Luttinger, D. ; Nemeroff, Charles ; Mason, G. A. ; Frye, G. D. ; Breese, G. R. ; Prange, A. J. / Enhancement of ethanol-induced sedation and hypothermia by centrally administered neurotensin, β-endorphin and bombesin. In: Neuropharmacology. 1981 ; Vol. 20, No. 3. pp. 305-309.
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