Enhancement of ethanol-induced sedation and hypothermia by centrally administered neurotensin, β-endorphin and bombesin

D. Luttinger, C. B. Nemeroff, G. A. Mason, G. D. Frye, G. R. Breese, A. J. Prange

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Intracisternal administration of three endogenous neuropeptides (neurotensin, β-endorphin, or bombesin) potentiated the duration of sedation induced by a fixed dose of ethanol (5.2 g/kg) in mice. The minimally effective dose of each peptide that enhanced ethanol-induced sedation was: neurotensin, 0.18 nmoles; β-endorphin, 1.79 nmoles; and bombesin, 0.06 nmoles. The enhancement of ethanol-induced sedation was correlated with the potentiation of ethanol-induced hypothermia for all three peptides. None of the neuropeptides studied significantly altered blood or brain ethanol concentrations, suggesting that the observed effects were not due to differences in ethanol metabolism.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalNeuropharmacology
Volume20
Issue number3
DOIs
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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